血液净化治疗儿童难治性肾病综合征短期疗效分析  

Analysis of Short-term Efficacy of Blood Purification in Children with Refractory Nephrotic Syndrome

作　　者：潘艳艳[1] 孙永超 PAN Yanyan;SUN Yongchao(Department of Pediatrics,Ji´nan Children´s Hospital,Ji´nan,Shandong Province,250022 China;Department of Clinical Nursing,Ji´nan Nursing Vocational College,Ji´nan,Shandong Province,250203 China)

机构地区：[1]济南市儿童医院儿内科,山东济南250022 [2]济南护理职业学院临床护理系,山东济南250203

出　　处：《系统医学》2023年第5期19-22,29,共5页Systems Medicine

基　　金：2021年济南市卫生健康委员会科技计划项目(2021-2-101)。

摘　　要：目的探究血液净化治疗儿童难治性肾病综合征的短期疗效,并评估其治疗安全性及对患儿血液相关指标的影响。方法选取2021年5月—2022年5月于济南市儿童医院儿内科就诊并接受系统治疗的难治性肾病综合征患儿60例为研究对象,采用随机数表法将其分为对照组(n=30)及观察组(n=30)。对照组采用常规治疗方法,观察组在对照组的基础上采用血液净化治疗。对比两组患儿短期治疗效果、血液不同指标水平以及不良反应发生率。结果观察组治疗有效率为96.67%,高于对照组的73.33%,差异有统计学意义(χ^(2)=4.706,P<0.05)。治疗前,两组患儿的UR、BUN、Cr、CCR水平以及尿量对比,差异无统计学意义(P>0.05);治疗后1周及2周,两组Cr、UR及BUN水平均降低,CCR及尿量均升高,且观察组的Cr、UR、BUN水平均低于对照组,CCR、尿量均高于对照组,差异有统计学意义(P<0.05)。观察组不良反应发生率为3.33%,低于对照组的6.67%,差异无统计学意义(χ^(2)=0.000,P>0.05)。结论血液净化治疗儿童难治性肾病综合征的短期疗效较好,可有效提高患儿的治疗有效率,改善血液相关指标,减少不良反应的发生,值得借鉴应用。Objective To explore the short-term curative effect of blood purification in the treatment of refractory nephrotic syndrome in children,and to evaluate the safety of the treatment and its influence on blood-related indicators in children.Methods 60 children with refractory nephrotic syndrome who received systematic treatment at the Pediatric Department of Ji'nan Children's Hospital from May 2021 to May 2022 were selected as the study subjects.They were randomly divided into a control group(n=30)and an observation group(n=30)using a random number method.The control group received routine treatment,while the observation group received blood purification treatment on the basis of the control group.Compared the short-term treatment effect,different blood index levels,and incidence of adverse reactions between the two groups of children.Results The effective rate of treatment in the observation group 96.67%was higher than that in the control group(73.33%),and the difference was statistically significant(χ^(2)=4.706,P<0.05).Before treatment,there was no statistically significant difference in the levels of UR,BUN,Cr,CCR,and urine output between the two groups of children(P>0.05);after 1 week and 2 weeks of treatment,Cr,UR,and BUN decreased in both groups,while CCR and urine volume increased,the levels of Cr,UR,and BUN in the observation group were lower than those in the control group,while CCR and urine volume were higher than those in the control group,and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group was 3.33%,lower than 6.67%in the control group,and the difference was not statistically significant(χ^(2)=0.000,P>0.05).Conclusion The short-term curative effect of blood purification in the treatment of refractory nephrotic syn-drome in children is good,which can effectively improve the treatment efficiency of children,improve blood-related indicators,and reduce the occurrence of adverse reactions,which is worthy of reference and application.

关 键 词：血液净化 儿童 难治性肾病综合征 短期疗效 血液指标 不良反应 

分 类 号：R473[医药卫生—护理学]