血清ALB、AFP水平与胃癌根治术患者术后复发的关系分析  

Analysis of the Relationship between Serum ALB,AFP Levels and Postoperative Recurrence in Patients with Radical Gastrectomy

作　　者：项立辰 朱雯 陆音婕 XIANG Lichen;ZHU Wen;LU Yinjie(Department of Clinical Laboratory,Xiangcheng People´s Hospital of Suzhou City,Suzhou,Jiangsu Province,215131 China)

机构地区：[1]苏州市相城人民医院检验科,江苏苏州215131

出　　处：《系统医学》2023年第5期46-50,共5页Systems Medicine

摘　　要：目的探究血清白蛋白(ALB)、甲胎蛋白(AFP)水平与胃癌根治术患者术后复发的关系。方法选取2015年7月—2020年6月苏州市相城人民医院收治的105例胃癌根治术患者作为研究对象,术后随访3~48个月,6例患者失访,其余99例患者根据术后复发情况分为复发组(n=58)与未复发组(n=41)。收集并比较两组患者临床资料,血清ALB、AFP水平,通过Logistic多因素分析影响胃癌根治术患者术后复发的因素,并进行Spearman分析血清ALB、AFP水平与胃癌根治术患者术后复发的相关性。结果两组患者性别、年龄、吸烟史、饮酒史、肿瘤数目、术后并发症情况、ALT及AST水平比较,差异无统计学意义(P>0.05);复发组患者TNM分期Ⅲ期,肿瘤大小≥5 cm,肿瘤浸润深度T3~4的占比及AFP水平高于未复发组,血清ALB水平低于未复发组,差异有统计学意义(P<0.05)。经Logistic多因素回归分析,TNM分期、肿瘤大小、肿瘤浸润深度、ALB及AFP水平是胃癌根治术患者术后复发的独立危险因素[OR(95%CI):3.651(1.605~8.305)、OR(95%CI):3.695(1.624~8.406)、OR(95%CI):3.959(1.740~9.006)、OR(95%CI):3.554(1.562~8.084)、OR(95%CI):4.092(1.799~9.308),P<0.05]。经Spearman分析,血清ALB与术后复发率呈负相关,AFP水平与术后复发率呈正相关(P<0.05)。结论血清ALB、AFP水平是胃癌根治术患者术后复发的独立危险因素,胃癌根治术患者术后复发与血清ALB、AFP水平密切相关。Objective To explore the relationship between serum albumin(ALB),alpha-fetoprotein(AFP)levels and postoperative recurrence in patients with radical gastrectomy.Methods From July 2015 to June 2020,105 patients with radical gastrectomy for gastric cancer admitted to Xiangcheng People´s Hospital of Suzhou were selected as the study subjects.The postoperative follow-up ranged from 3 to 48 months,and 6 patients were lost to follow-up.The remaining 99 patients were divided into recurrence group(n=58)and non-relapse group(n=41)according to the postoperative recurrence.The clinical data and serum ALB and AFP levels of patients in the two groups were collected and compared.The factors affecting postoperative recurrence in patients with radical gastrectomy were analyzed by Logistic multivariate analysis,and the correlation between serum ALB and AFP levels and postoperative recurrence in patients with radical gastrectomy was analyzed by Spearman.Results There was no statistically significant difference in gender,age,smoking history,drinking history,tumor number,postoperative complications,ALT and AST levels between the two groups(P>0.05);the proportion of patients with TNM stageⅢ,tumor size≥5 cm,tumor infiltration depth T3~4 and AFP level in the recurrence group were higher than those in the non-relapse group,and the serum ALB level was lower than that in the non-relapse group,the difference was statistically significant(P<0.05).Through logis-tic regression analysis,TNM staging,tumor size,depth of tumor infiltration,ALB,and AFP levels were independent risk factors for postoperative recurrence in patients undergoing radical gastrectomy for gastric cancer[OR(95%CI):3.651(1.605-8.305),OR(95%CI):3.695(1.624-8.406),OR(95%CI):3.959(1.740-9.006),OR(95%CI):3.554(1.562-8.084),OR(95%CI):4.092(1.799-9.308),P<0.05].According to Spearman analysis,serum ALB was nega-tively correlated with postoperative recurrence rate,and AFP level was positively correlated with postoperative recur-rence rate(P<0.05).Conclusion Serum ALB and AFP lev

关 键 词：白蛋白 甲胎蛋白 胃癌根治术 术后复发 相关性 

分 类 号：R4[医药卫生—临床医学]