急性心肌梗死患者行不同时机经皮冠状动脉介入治疗改善心功能的机制研究  

Study on the Mechanism of Improving Cardiac Function by Different Timing of Percutaneous Coronary Intervention in Patients with Acute Myocardial Infarction

作　　者：武赟堂 WU Yuntang(Department of Cardiology II,Handan Fourth Hospital,Handan,Hebei Province,056200 China)

机构地区：[1]邯郸市第四医院心内二科,河北邯郸056200

出　　处：《系统医学》2023年第4期109-112,共4页Systems Medicine

基　　金：河北省自然科学基金(H2018206115);邯郸市科技计划项目(1623208066-6)。

摘　　要：目的探讨急性心肌梗死患者(acute myocardial infarction,AMI)行不同时机经皮冠状动脉介入治疗(percutaneous coronary intervention,PCI)对其心功能及预后的影响。方法选取2019年9月—2021年8月邯郸市第四医院收治的60例AMI患者,依据随机数表法分为对照组和观察组,每组30例。对照组于发病至就诊时间超过24 h行PCI,观察组于发病至就诊时间24 h内行PCI,两组均于术后随访6个月。比较两组临床疗效、治疗前后心功能指标和心肌受损指标。结果治疗后,观察组临床总有效率(96.67%)比对照组(73.33%)高,差异有统计学意义(χ^(2)=4.706,P<0.05);与治疗前比较,治疗后6个月两组LVDEd、LVSEd、LAd水平均降低,且观察组比对照组低,差异有统计学意义(P<0.05);治疗后5 d两组血清BNP、cTnT、CK-MB水平均降低,且观察组比对照组低,差异有统计学意义(P<0.05)。结论尽早对AMI患者行PCI治疗可明显改善心功能,恢复心肌功能。Objective To investigate the effect of percutaneous coronary intervention(PCI)on cardiac function and prognosis in patients with acute myocardial infarction(AMI)at different times.Methods Sixty patients with AMI admitted to Handan Fourth Hospital from September 2019 to August 2021 were selected and divided into control and observation groups based on the random number table method,with 30 cases in each group.In the control group,PCI was performed more than 24 h from the onset to the time of consultation,and in the observation group,PCI was performed within 24 h from the onset to the time of consultation,and both groups were followed up for 6 months after surgery.The clinical efficacy,cardiac function index and myocardial damage index were compared between the two groups.Results After treatment,the total clinical efficiency of the observation group(96.67%)was higher than that of the control group(73.33%),and the difference was statistically significant(χ^(2)=4.706,P<0.05).Compared with the pre treatment period,the levels of LVDEd,LVSEd and LAd in both groups reduced 6 months after treatment,and the observation group was lower than the control group,and the difference was statistically significant(P<0.05).Serum BNP,cTnT,and CK-MB levels reduced in both groups at 5 d after treatment,and the observation group was lower than the control group,and the difference was statistically significant(P<0.05).Conclusion Early PCI treatment for AMI patients can significantly improve cardiac function,restore myocardial function.

关 键 词：急性心肌梗死 经皮冠状动脉介入 心功能 

分 类 号：R542[医药卫生—心血管疾病]