“养心-疏肝-补肾”健康管理模式对围绝经综合征患者的临床疗效评价  

Clinical Efficacy Evaluation of"Nourishing Heart-soothing Liver tonifying Kidney"Health Management Model on Patients with Perimenopausal Syndrome

作　　者：孙凤丹[1] 贾丹 孙徐祎 孙淑梅 宋清霞[1] SUN Fengdan;JIA Dan;SUN Xuyi;SUN Shumei;SONG Qingxia(Department of Gynecology,Suzhou Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Traditional Chinese Medicine,Suzhou,Jiangsu Province,215000 China)

机构地区：[1]南京中医药大学附属苏州市中医医院妇科,江苏苏州215000

出　　处：《系统医学》2023年第4期159-163,共5页Systems Medicine

基　　金：苏州市科技局指导性专项课题(SKY2021057);苏州市院级课题(KY20097)。

摘　　要：目的评估“养心-疏肝-补肾”健康管理模式对围绝经综合征患者的临床疗效。方法选取2020年10月—2022年6月期间南京中医药大学附属苏州市中医医院符合纳入标准的围绝经综合征(perimenopausal syndrome,PMS)患者180例,随机分为观察组和对照组,每组90例。观察组采用“养心-疏肝-补肾”健康管理模式,对照组采用常规治疗模式。对比患者治疗前后的Kupperman评分、Greene评分、Zung评分、血清性激素、CD8^(+)、CD4^(+)及CD4^(+)/CD8^(+)、生化指标、中医证候积分变化及临床疗效情况。结果治疗后,观察组的Kupperman评分明显低于对照组,差异有统计学意义(P<0.05)。观察组DHEAs浓度高于对照组,差异有统计学意义(P<0.05)。观察组CD4^(+)、CD4^(+)/CD8^(+)较对照组上升,差异有统计学意义(P<0.05)。观察组患者胆固醇水平和低于对照组,高密度脂蛋白水平高于对照组,差异有统计学意义(P<0.05)。观察组中医证候积分低于对照组,差异有统计学意义(P<0.05),观察组患者临床治疗总有效率为83.33%显著高于对照组,差异有统计学意义(χ^(2)=4.472,P=0.034)。结论“养心-疏肝-补肾”健康管理方案对围绝经综合征患者有较好的临床疗效,能缓解围绝经期患者临床症状,调节患者性激素水平,预防心血管事件的远期发生,在改善中医临床证候方面有一定优势。Objective To evaluate the clinical efficacy of the health management model of"nourishing the heart soothing the liver-tonifying the kidney"on patients with perimenopausal syndrome.Methods 180 patients with perimenopausal syndrome(PMS)who met the inclusion criteria from October 2020 to June 2022 at Suzhou Traditional Chinese Medicine Hospital affiliated with Nanjing University of Traditional Chinese Medicine were selected and randomly divided into an observation group and a control group,with 90 patients in each group.The observation group adopted a health management model of"nourishing the heart,soothing the liver,and tonifying the kidney",while the control group adopted a routine treatment mode.Compared the Kupperman score,Greene score,Zung score,serum sex hormones,CD8^(+),CD4^(+),and CD4^(+)/CD8^(+),biochemical indicators,changes in traditional Chinese medicine syndrome scores,and clinical efficacy of patients before and after treatment.Results After treatment,the Kupperman score of the observation group was significantly lower than that of the control group,the difference was statistically significant(P<0.05).The concentration of DHEAs in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).The CD4^(+)and CD4^(+)/CD8^(+)levels in the observation group increased significantly compared to the control group,the difference was statistically significant(P<0.05).The levels of cholesterol in the observation group were lower than those in the control group,while the levels of high-density lipoprotein were higher than those in the control group,the difference was statistically significant(P<0.05).The TCM syndrome score of the observation group was lower than that of the control group,the difference was statistically significant(P<0.05).The total clinical treatment effective rate of the observation group patients was 83.33%,which was significantly higher than that of the control group,the difference was statistically significant(χ^(2)=4.472,P=0.034).Co

关 键 词：围绝经综合征 养心-疏肝-补肾 健康管理 临床疗效 

分 类 号：R711[医药卫生—妇产科学]