中药碳点的合成及其在生物成像和医学治疗方面的应用  

Synthesis of Traditional Chinese Medicines-Derived Carbon Dots for Bioimaging and Therapeutics

作　　者：何静 陈佳[1,2] 邱洪灯 Jing He;Jia Chen;Hongdeng Qiu(Lanzhou Institute of Chemical Physics,Chinese Academy of Sciences,Lanzhou 730000,China;University of Chinese Academy of Sciences,Beijing 101408,China)

机构地区：[1]中国科学院兰州化学物理研究所,兰州730000 [2]中国科学院大学,北京101408

出　　处：《化学进展》2023年第5期655-682,共28页Progress in Chemistry

基　　金：中国科学院“西部之光”人才培养计划(No.xbzg-zdsys-202008);中国科学院青年创新促进会(No.2021420)资助。

摘　　要：碳点(Carbon dots,CDs)作为一类粒径小于10 nm新型零维光致发光纳米材料,具备可调荧光发射和激发波长,良好的光稳定性、水溶性和生物相容性、低毒性等显著优势,近年来得到了学者们广泛关注。以富含多种活性成分并可发挥多种药效作用的中药(Traditional Chinese Medicines,TCM)为碳源,制备出具有一些特殊功能的中药CDs(TCM-CDs),进而有望发挥出更大的药用价值。本文详细介绍了中药CDs的合成方法及每种合成方法的优缺点,全面综述了中药碳点在生物成像和医学治疗方面的最新研究进展,并对中药CDs研究的重要性及面临的主要问题及挑战和未来的发展方向进行了展望。Carbon dots(CDs),with particle size less than 10 nm,are a new type of zero-dimensional photoluminescence nanomaterials.Due to the obvious advantages of adjustable fluorescence emission and excitation wavelength,light stability,low toxicity,good water solubility and biocompatibility,etc.,CDs have been widely researched in recent years.As a treasure of ancient Chinese science,Traditional Chinese medicine(TCM)is rich in various active ingredients and plays a variety of pharmacodynamic effects,which has been used for thousands of years.TCM-CDs prepared with TCM as carbon source can create some special functions,and then may play a greater medicinal value.In this paper,the synthesis of TCM-CDs and its application in biological imaging and medical therapy are reviewed.Firstly,different synthetic methods of TCM-CDs(including hydrothermal,pyrolysis,solvothermal and microwave assisted method)are introduced in detail,and their advantages and disadvantages are compared.Subsequently,the latest research on TCM-CDs in biological imaging and medical treatment is comprehensively analyzed.This paper focuses on the application of imaging different types of cells in vitro and the distribution and uptake of TCM-CDs guided by imaging in vivo(mice,zebrafish,etc.).In addition,the intrinsic pharmacological activities of these TCM-CDs(including antibacterial,anti-inflammatory,hemostatic,antioxidant and anticancer,etc.)and their mechanisms are also discussed in order to improve and promote their clinical application.Finally,the importance of TCM-CDs research,the main problems and challenges in this fields and the future development direction are summarized and outlooked.

关 键 词：碳点 中药 合成方法 生物成像 医学治疗 

分 类 号：O613.71[理学—无机化学]