刺激响应性聚合物微针系统经皮药物递释  

Stimuli-Responsive Polymer Microneedle System for Transdermal Drug Delivery

作　　者：张婉萍 刘宁宁 张倩洁 蒋汶 王梓鑫 张冬梅 Wanping Zhang;Ningning Liu;Qianjie Zhang;Wen Jiang;Zixin Wang;Dongmei Zhang(School of Perfume and Aroma Technology,Shanghai Institute of Technology,Shanghai 201418,China)

机构地区：[1]上海应用技术大学香料香精化妆品学部,上海201418

出　　处：《化学进展》2023年第5期735-756,共22页Progress in Chemistry

基　　金：省部共建协同创新中心项目(No.XTCXC-202101);上海应用技术大学协同创新基金项目(No.XTCX2022-30)资助。

摘　　要：微针经皮递送系统相比于口服、注射给药具有高效、安全、无痛的给药特点,特别是刺激响应性聚合物微针系统生物相容性好,能够依据环境微变化实现时间和空间上的经皮局部和全身智能给药功能,是当前国际前沿研究课题。本文聚焦于近十年来国内外刺激响应性聚合物微针系统的研究工作,着重综述了聚合物微针的发展演变历程、内外环境刺激响应类型及其响应构效机制。此外,详细阐述了微针制备方法、表征方法、微针系统在生物医药递释、组织器官、皮肤医学及医美领域等方面的应用。刺激响应性聚合物微针系统使用方法简便、力学性能可调、药物精准靶向递送,在经皮靶向给药领域有重大研究意义,未来生物活体负载及标准化的产业应用是研究者不断努力和进步的方向。Compared with oral administration and injection administration,the microneedle transdermal delivery system has the characteristics of high efficiency,safety and painless administration.In particular,the stimuliresponsive polymer microneedle systems exhibit good biocompatibility and can be realized according to the microchanges in the environment.The function of percutaneous local and systemic intelligent drug delivery in time and space is currently an international frontier research topic.This paper focuses on the research of stimulusresponsive polymer microneedles at home and abroad in the past ten years,and focuses on the evolution of polymer microneedles,the types of internal and external environmental stimulus response and its response structure-activity mechanism.In addition,the preparation and characterization of microneedles and the application of microneedle system in the fields of biomedicine delivery,tissue and organs,dermatology and medical beauty are described in detail.The stimulation-responsive polymer microneedle system hasthe advantages of simple use,adjustable mechanical properties and precise targeted drug delivery,which has great research significance in the field of percutaneous targeted drug delivery.In the future,the biological in vivo load and industrial application of standardization are the direction of continuous efforts and progress of researchers.

关 键 词：聚合物微针 刺激响应性 经皮药物递释 疾病治疗 

分 类 号：O631[理学—高分子化学] R94[理学—化学]