Photothermal‑Triggered Structural Change of Nanofiber Scaffold Integrating with Graded Mineralization to Promote Tendon–Bone Healing  

作　　者：Chenghao Yu Tianrui Wang Hongcui Diao Na Liu Yi Zhang Hongyuan Jiang Peng Zhao Zhengyi Shan Zewen Sun Tong Wu Xiumei Mo Tengbo Yu 

机构地区：[1]Department of Sports Medicine,Affiliated Hospital of Qingdao University,Qingdao 266061,Shandong,China [2]Institute of Neuroregeneration and Neurorehabilitation,Qingdao Medical College,Qingdao University,Qingdao 266071,Shandong,China [3]Shandong Key Laboratory of Textile Materials for Healthcare,Collaborative Innovation Center for Eco-Textiles of Shandong Province and the Ministry of Education,308 Ningxia Road,Qingdao 266071,Shandong,China [4]State Key Lab for Modification of Chemical Fibers and Polymer Materials,College of Chemistry,Chemical Engineering and Biotechnology,Donghua University,Shanghai 201620,China [5]Department of Endocrinology,Jinan Central Hospital Affiliated To Shandong University,No.105 Jiefang Road,Jinan 250013,Shandong,China

出　　处：《Advanced Fiber Materials》2022年第4期908-922,共15页先进纤维材料（英文）

基　　金：This research was supported by National Natural Science Foundation of China(31872310,82001970);Natural Science Foundation of Shandong Province(ZR2019MH097,ZR2021YQ17);Young Elite Scientists Sponsorship Program by CAST(No.YESS20200097);startup funds from Qingdao University(T.W.).

摘　　要：Scaffolds functionalized with graded changes in both fiber alignment and mineral content are more appealing for tendon-bone healing.This study reports the healing of rotator cuff injury using a heterogeneous nanofiber scaffold,which is associated with a structural gradating from aligned to random and an increasing gradient of mineral content in the same orientation.The photothermal-triggered structural change of a nanofiber scaffold followed by graded mineralization is key to constructing such scaffolds.This type of scaffold was found to be biocompatible and provide beneficial contact guidance in the manipulation of tendon-derived stem cell morphologies in vitro.Specifically,tenogenic and osteogenic differentiation of tendon-derived stem cells were simultaneously achieved using the fabricated scaffold.In vivo investigation also showed the improved healing of rabbit rotator cuff injuries based on immunohistochemical analysis and biomechanical investigation that indicates the promising potential of a dual-gradient nanofiber scaffold in clinical tendon-bone healing.

关 键 词：Photothermal welding Graded mineralization Nanofiber scaffold Tendon-derived stem cells Tendon-tobone healing 

分 类 号：TB383[一般工业技术—材料科学与工程]