慢性活动性EB病毒感染相关基因改变的研究进展  

Advances in genetic alterations associated with chronic active Epstein-Barr virus infection

作　　者：胡飞 彭梅娟 詹家燚 连建奇 HU Fei;PENG Meijuan;ZHAN Jiayi;LIAN Jianqi(Department of Infectious Diseases,the Second Affiliated Hospital of Air Force Medical University,Xi’an 710038,China)

机构地区：[1]空军军医大学第二附属医院传染科,西安710038

出　　处：《传染病信息》2023年第3期272-277,共6页Infectious Disease Information

基　　金：“十三五”国家科技重大专项(2017ZX10204401)。

摘　　要：EB病毒(Epstein-Barr virus,EBV)属于疱疹病毒γ亚科,是导致传染性单核细胞增多症、慢性活动性EBV感染(chronic active Epstein-Barr virus infection,CAEBV)、多种淋巴细胞和上皮细胞相关恶性肿瘤的病原体。CAEBV属于EBV阳性T细胞或NK细胞增生性疾病,发病机制尚未明确,治疗方法有限,预后差。本文就CAEBV发病中相关基因改变的最新研究进展进行综述,为CAEBV的进一步研究和诊治提供依据。Epstein-Barr virus is the causal agent,a member of herpesvirus 4,which is associated with infectious mononucleosis,chronic active Epstein-Barr virus infection(CAEBV)and a range of malignancies from lymphocyte and epithelial cell.CAEBV belongs to EBV positive T cell or NK cell lymphoproliferative diseases.The pathogenesis of CAEBV remains unclear,the treatment options are limited with a poor prognosis.This article reviews the latest research progress of related gene changes in the pathogenesis of CAEBV,so as to provide a basis for further research on CAEBV diagnosis and therapy.

关 键 词：EB病毒 慢性活动性EB病毒感染 致病机制 潜伏感染 裂解感染 

分 类 号：R373[医药卫生—病原生物学]