前列腺特异性抗原检测用于诊断早期前列腺增生的价值  

Value of Prostate-Specific Antigen Test for Diagnosis of Early Prostatic Hyperplasia

作　　者：杜林 王曼丽 左林 Du Lin;Wang Man-li;Zuo Lin(Department of Clinical Laboratory,Xingyi People's Hospital,Xingyi 562400,Guizhou Province,China)

机构地区：[1]兴义市人民医院检验科,贵州兴义562400

出　　处：《中国社区医师》2023年第16期107-109,共3页Chinese Community Doctors

摘　　要：目的:探讨前列腺特异性抗原(PSA)检测的用于早期前列腺增生的诊断价值。方法:选取2020年3月-2021年9月兴义市人民医院收治的前列腺疾病患者85例为观察组,其中良性前列腺增生45例(增生组),前列腺癌40例(癌症组),选取同期体检健康者50例为对照组,均行临床检测,包括外周血肿瘤特异性生长因子(TSGF)、前列腺酸性磷酸酶(PAP)以及前列腺特异性抗原(PSA)。比较观察组与对照组各指标水平,增生组与癌症组不同PSA水平时各指标水平,联合检测与单一检测的诊断价值。结果:观察组PSA、PAP、TSGF水平高于对照组,差异有统计学意义(P<0.05)。PSA≤4 ng/mL、4<PSA≤10 ng/mL时,增生组PAP、TSGF、PSA水平低于癌症组,差异有统计学意义(P<0.001);10<PSA≤20 ng/mL时,增生组PAP、TSGF水平低于癌症组,差异有统计学意义(P<0.05);PSA>20 ng/mL时,增生组PAP和PSA水平低于癌症组,差异有统计学意义(P<0.05)。癌症组TSGF检测阳性率高于增生组,差异有统计学意义(P<0.05);联合检测前列腺增生阳性率高于单一检测,差异有统计学意义(P<0.05)。结论:在早期前列腺增生患者的临床诊断中,运用PSA检测可以与前列腺癌进行鉴别,联合TSGF和PAP检测能够提高早期诊断准确率,为制定针对性治疗方案和判断预后提供一定的参考依据。Objective:To investigate the value of prostate-specific antigen(PSA)test in the diagnosis of early prostatic hyperplasia.Methods:From March 2020 to September 2021,85 patients with prostate disease admitted to Xingyi People's Hospital were selected as the observation group,including 45 cases of benign prostatic hyperplasia(hyperplasia group),40 cases of prostate cancer(cancer group).Fifty healthy people for physical examination during the same period were selected as the control group.All the subjects received clinical tests,including peripheral blood tumor-specific growth factor(TSGF),prostate acid phosphatase(PAP)and prostate-specific antigen(PSA).The levels of each index in the observation group and the control group,the levels of each index in the hyperplasia group and the cancer group at different PSA levels,and the diagnostic value of combined detection and single detection were compared.Results:The levels of PSA,PAP and TSGF in the observation group were higher than those in the control group,and the difference was statistically significant(P<0.05).When PSA≤4 ng/mL,4<PSA≤10 ng/mL,the levels of PAP,TSGF and PSA in the hyperplasia group were lower than those in the cancer group,and the difference was statistically significant(P<0.001);When 10<PSA≤20 ng/mL,the levels of PAP and TSGF in the hyperplasia group were lower than those in the cancer group,and the difference was statistically significant(P<0.05);When PSA>20 ng/mL,the levels of PAP and PSA in the hyperplasia group were lower than those in the cancer group,and the difference was statistically significant(P<0.05).The positive rate of TSGF test in the cancer group was higher than that in the hyperplasia group,and the difference was statistically significant(P<0.05);The positive rate of prostatic hyperplasia by the combined detection was higher than that by the single detection,and the difference was statistically significant(P<0.05).Conclusion:In the clinical diagnosis of patients with early prostatic hyperplasia,the use of PSA test can differentiat

关 键 词：肿瘤特异性生长因子 前列腺酸性磷酸酶 前列腺特异性抗原 前列腺增生 前列腺癌 

分 类 号：R697.3[医药卫生—泌尿科学]