甲状腺细针穿刺液基细胞学Ⅲ类患者CK19、Galectin-3、HBME-1、TPO抗体检测及其临床意义  

Detection of CK19,Galectin-3,HBME-1,and TPO antibodies in patients with thyroid fine needle aspiration liquid-based cytology classⅢand their clinical significance

作　　者：张晓惠 曹晓云 文钰玲 ZHANG Xiao-hui;CAO Xiao-yun;WEN Yu-ling(Department of Pathology,Xi'an Baoshihua Changqing Hospital,Xi'an 710201,Shaanxi,CHINA;Department of Obstetrics and Gynecology,Xi'an Baoshihua Changqing Hospital,Xi'an 710201,Shaanxi,CHINA)

机构地区：[1]西安宝石花长庆医院病理科,陕西西安710201 [2]西安宝石花长庆医院妇产科,陕西西安710201

出　　处：《海南医学》2023年第13期1915-1918,共4页Hainan Medical Journal

摘　　要：目的检测甲状腺细针穿刺液基细胞学Ⅲ类患者细胞角蛋白19(CK19)、半乳糖凝素-3(Galectin-3)、间皮细胞(HBME-1)、甲状腺过氧化物酶(TPO)抗体水平,并探讨其临床意义。方法回顾性分析2019年1月至2020年12月西安宝石花长庆医院收治的100例甲状腺细针穿刺液基细胞学Ⅲ类患者的临床资料,所有患者均经手术取得病理诊断结果,依据病理诊断结果分为良性组65例和甲状腺乳头状癌组35例。检测并比较两组患者CK19、Galectin-3、HBME-1、TPO阳性率,同时比较其诊断甲状腺乳头状癌的准确性、敏感性、特异性、阴性预测值及阳性预测值。结果甲状腺乳头状癌组患者的CK19、Galectin-3、HBME-1阳性率分别为97.14%、91.43%、85.71%,明显高于良性组的6.15%、3.08%、7.69%,TPO阳性率为5.71%,明显低于良性组的93.85%,差异均有统计学意义(P<0.05);CK19、Galectin-3、HBME-1、TPO及四者联合诊断甲状腺乳头状癌的准确性、敏感性、特异性、阴性预测值和阳性预测值比较差异均无统计学意义(P>0.05)。结论甲状腺细针穿刺液基细胞学Ⅲ类患者CK19、Galectin-3、HBME-1、TPO抗体检测可显著提升细胞学诊断效能,有较大的应用价值。Objective To determine the levels of cytokeratin 19(CK19),Galectin-3(Galectin-3),mesenchy-mal cells(HBME-1),and thyroid peroxidase(TPO)antibodies in patients with thyroid fine needle aspiration liq-uid-based cytology classⅢ,and to investigate its clinical significance.Methods The clinical data of 100 patients with thyroid fine needle aspiration liquid-based cytology classⅢadmitted to Xi'an Baoshihua Changqing Hospital from Jan-uary 2019 to December 2020 were retrospectively analyzed.All patients obtained pathological diagnosis results after sur-gery.The patients were divided into benign group(65 cases)and papillary thyroid cancer group(35 cases)according to the pathological diagnosis results.The positive rates of CK19,Galectin-3,HBME-1,and TPO in the two groups were detected and compared,and the accuracy,sensitivity,specificity,negative predictive value,and positive predictive value of papillary carcinoma of the thyroid were compared.Results The positive rates of CK19,Galectin-3,and HBME-1 in the papillary thyroid cancer group were 97.14%,91.43%,and 85.71%,which were significantly higher than 6.15%,3.08%,and 7.69%in the benign group;the positive rate of TPO was 5.71%,which was significantly lower than 93.85%in the benign group;the differences were statistically significant(P<0.05).There was no statistically significant differ-ence in the accuracy,sensitivity,specificity,negative predictive value,and positive predictive value of CK19,Galec-tin-3,HBME-1,TPO,and their combination in the diagnosis of papillary thyroid cancer(P>0.05).Conclusion The detection of CK19,Galectin-3,HBME-1,and TPO antibodies in patients with thyroid fine needle aspiration liq-uid-based cytology classⅢcan significantly improve the diagnostic efficiency of cytology and has great application value.

关 键 词：液基细胞学Ⅲ类 细针穿刺 甲状腺 细胞角蛋白19 半乳糖凝素-3 间皮细胞 甲状腺过氧化物酶 临床意义 

分 类 号：R581[医药卫生—内分泌]