高尿酸血症患者肾脏尿酸排泄能力检测方法  

Measurement method of renal uric acid excretion ability in patients with hyperuricemia

作　　者：刘悦 王悦[1] LIU Yue;WANG Yue(Department of Nephrology,Peking University Third Hospital,Beijing 100191,China)

机构地区：[1]北京大学第三医院肾内科,北京100191

出　　处：《中国血液净化》2023年第5期381-383,共3页Chinese Journal of Blood Purification

摘　　要：高尿酸血症患者约90%存在肾脏尿酸排泄能力降低,国内外指南或共识推荐或建议用24小时尿酸排泄分数和/或24小时尿酸排泄量评估肾脏尿酸排泄水平、指导临床分型及用药选择。24小时尿液收集耗时较长,存储和保管条件不一,容易污染和遗漏,影响结果及时性和准确性。研究发现晨尿尿酸排泄分数可以简便、高效以及较好地代替24小时尿尿酸排泄分数评估高尿酸血症患者肾脏尿酸排泄能力,及时指导临床分型和用药。About 90%of the hyperuricemia patients are found to have renal dysfunction of uric acid ex-cretion.Guidelines and consensus from China and foreign countries have recommend that the 24-hour uric ac-id excretion fraction and/or 24-hour uric acid excretion can be used for assay of renal uric acid excretion abili-ty,clinical classification and drug selection.However,collection of a 24-hour urine sample takes a long time,and the result may not be accurate due to the possible contamination and incomplete sampling during collec-tion and limited urine storage condition.Previous studies have found that uric acid excretion fraction in ran-dom urine sample,especially in morning urine sample,is a simple and efficient method,which may replace the 24-hour uric acid excretion method to evaluate renal uric acid excretion function and to guide clinical clas-sification and treatment in hyperuricemia patients.

关 键 词：高尿酸血症 肾脏尿酸排泄不良 尿酸排泄分数 24小时尿 晨尿 

分 类 号：R446.1[医药卫生—诊断学]