健听幼儿短纯音ABR波V强度-潜伏期函数模型构建  

Functional Model Construction of Wave V Intensity-latency Based on Tone Burst Auditory Brainstem Responses in Infants with Normal Hearing

作　　者：马孝宝 沈佳丽 汪玮[1] 王璐[1] 孙进 贺宽 陈向平 杨军[1] 陈建勇[1] Ma Xiaobao;Shen Jiali;Wang Wei;Wang Lu;Sun Jin;He Kuan;Chen Xiangping;Yang Jun;Chen Jianyong(Department of Otolaryngology-Head&Neck Surgery,Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine,Ear Institute Shanghai Jiaotong University School of Medicine Shanghai Key Laboratory of Translational Medicine of Ear and Nose Disease,Shanghai,200092,China)

机构地区：[1]上海交通大学医学院附属新华医院耳鼻咽喉头颈外科,上海交通大学医学院耳科学研究所,上海市耳鼻疾病转化医学重点实验室,上海200092

出　　处：《听力学及言语疾病杂志》2023年第4期299-304,共6页Journal of Audiology and Speech Pathology

基　　金：上海市科委项目(21S31900600);新华医院院级临床研究培育基金(21XHDB02)。

摘　　要：目的构建听力正常婴幼儿不同频率短纯音听性脑干反应(TB-ABR)波V强度-潜伏期函数曲线,为临床TB-ABR反应阈的判断提供参考。方法选取40例(80耳)听力正常婴幼儿作为研究对象,月龄3~12月,平均7.2±2.8月。分别选取70、60、50、40、30 dB nHL 5个不同刺激强度进行TB-500、TB-1000、TB-2000和TB-4000 Hz 4个频率的TB-ABR检测,记录不同强度下各频率的波V潜伏期,使用SPSS 26.0进行统计学分析,建立各频率不同强度下的强度-潜伏期函数模型。结果①同一强度不同频率下的波V潜伏期差异均有统计学意义(P<0.05);②阈值强度下不同频率下的波V潜伏期差异均有统计学意义(P<0.05);③同一频率不同强度波V潜伏期差异均有统计学意义(P<0.05);④不同刺激频率下的强度-潜伏期函数模型分别为TB-500 Hz:y=-0.09 x+16.59;TB-1000 Hz:y=-0.07 x+13.73;TB-2000 Hz:y=-0.05 x+10.61;TB-4000 Hz:y=-0.04 x+9.44。结论TB-ABR的波V潜伏期随刺激声频率和/或强度的升高而逐渐缩短,本研究建立的不同频率不同强度下的TB-ABR强度-潜伏期函数模型可为本实验室临床提供参考。Objective To construct the tone burst auditory brainstem responses(TB-ABR)wave V intensity-latency function curve of different frequencies in infants with normal hearing,and to provide a reference for the determination of clinical TB-ABR response threshold.Methods Forty infants(80 ears)with normal hearing were selected for this study.The age distribution was from 3 to 12 months and the mean age was 7.2±2.8 months.Five different stimulus intensities of 70,60,50,40,and 30 dB nHL were selected for TB-ABR testing at four frequencies of TB-500 Hz,TB-1000 Hz,TB-2000 Hz,and TB-4000 Hz.Wave V latency of each frequency at different intensities were recorded and statistically analyzed using SPSS 26.0 to establish the intensity-latency functional model for each frequency.Results The differences in wave V latencies at different frequencies were statistically significant(P<0.05).The difference in wave V latencies of at different intensities were statistically significant(P<0.05).The differences in wave V latencies at different threshold intensity level were statistically significant(P<0.05).The intensity-latency functional models at different frequencies were TB-500 Hz:y=-0.09 x+16.59;TB-1000 Hz:y=-0.07 x+13.73;TB-2000 Hz:y=-0.05 x+10.61;TB-4000 Hz:y=-0.04 x+9.44,respectively.Conclusion The wave V latency of TB-ABR gradually shortens with the increase of the frequency and intensity.The intensity-latency functional model of TB-ABR at different frequencies and intensities established in this study can provide a reference for clinical practice.

关 键 词：婴幼儿 正常听力 短纯音听性脑干反应 强度-潜伏期 函数模型 

分 类 号：R339.16[医药卫生—人体生理学]