PGC-1a适应骨骼肌不同持续时间与强度收缩活动的研究进展  

Research Progress on PGC-1a Adaptation to Different Duration and Intensity of Skeletal Muscle Contraction Activities

作　　者：张海鹏 马继政 ZHANG Haipeng;MA Jizheng(Department of Exercise and Heath,Nanjing Sport Institute,Nanjing Jiangsu,210014,China;Research Center of Military Exercise Science,Army Engineering University of PLA,Nanjing Jiangsu,211101,China)

机构地区：[1]南京体育学院运动健康学院,江苏南京210014 [2]陆军工程大学军事运动科学研究中心,江苏南京211101

出　　处：《四川体育科学》2023年第4期23-32,共10页Sichuan Sports Science

摘　　要：本综述通过对PGC-1α依赖性信号传导的研究,描述不同持续时间、强度和模式的有氧运动,对调节骨骼肌线粒体生物合成的分子事件的影响。这对于治疗各种代谢性疾病以及优化运动训练计划至关重要。现有研究表明,30-90min的有氧运动无法提供额外的刺激来激活信号通路,以调节PGC-1α的翻译后修饰以及PPARGC1A的基因表达。而II型肌纤维募集的增加,导致运动强度显著影响线粒体的生物合成并伴随着明显的代谢变化,从而导致信号级联反应的激活和调控线粒体生物合成的基因的表达。因此,间歇性运动比连续运动能更有效地激活线粒体生物合成。在适应有氧训练的骨骼肌中,通过运动强度激活线粒体生物合成,主要与AMP激活的蛋白激酶/PGC-1α通路,PGC-1α调控的基因的表达,以及来源于由cAMP反应元件结合蛋白1相关转录因子及其共激活因子调控的诱导型可变启动子AP的PPARGC1A的表达有关。This review focuses on PGC-1α-dependent signaling.Describing the effects of molecular mechanisms regulating mitochondrial biogenesis in skeletal muscles.It is important for treatment of patients with various metabolic disorders,as well as for optimization of training in athletes.Aerobic exercise from 30 to 90 min does not provide additional stimuli to activate signaling pathways regulating post-translational modification of PGC-1αand expression of PPARGC1A.Exercise intensity substantially affects mitochondrial biogenesis due to the increase in the recruitment of type II muscle fibers with accompanying pronounced metabolic shift leading to the activation of signaling cascades and expression of genes regulating mitochondrial biogenesis.Therefore,intermittent exercise is more efficient in the activation of mitochondrial biogenesis than work-matched continuous exercise.In skeletal muscle adapted to aerobic training,intensity-dependent activation of mitochondrial biogenesis after acute exercise is associated primarily with the AMP-activated protein kinase/PGC-1αpathway,expression of PGC-1α-regulated genes,and expression of PPARGC1A from the AP regulated by the cAMP response element-binding protein 1-related transcription factors and their coactivators.

关 键 词：运动时间 运动强度 过氧化物酶体增殖物激活受体γ共激活因子1α 5'-AMP激活蛋白激酶 

分 类 号：G804.22[文化科学—运动人体科学]