一款国产滤器与进口滤器治疗甲醇中毒的疗效观察  

Therapeutic effects of methanol poisoning using the hemodialyzer with a China-made filter and an imported filter

作　　者：赵苓杉 解德琼[1] 张臣丽[1] ZHAO Ling-shan;XIE De-qiong;ZHANG Chen-li(Department of Nephrology,The Second People's Hospital of Yibin City,Yibin 644000,China)

机构地区：[1]宜宾市第二人民医院肾病内科,宜宾644000

出　　处：《中国血液净化》2023年第6期477-480,共4页Chinese Journal of Blood Purification

基　　金：四川省科技计划项目(2019YJ0711)。

摘　　要：目的探究国产滤器威高HF17与进口滤器FX80(费森尤斯公司,德国)治疗甲醇中毒的临床效果。方法选取2022年3月宜宾市第二人民医院和宜宾市第五人民医院治疗的25名甲醇中毒行血液透析的患者作为研究对象,9名患者为HF17组,16名患者为FX80组。对比2组患者透析前后甲醇浓度、血气分析、住院天数。结果HF17组甲醇浓度差高于FX80组(t=-3.849,P=0.001),2组患者治疗后血气分析中pH值(FX80组t=-6.005,P<0.001;HF17组t=-3.501,P=0.008)及甲醇浓度(FX80组t=11.045,P<0.001;HF17组t=13.829,P<0.001)明显下降,治疗后2组间pH(t=13.829,P<0.001)、碱剩余(t=-0.528,P=0.603)、乳酸(t=-1.276,P=0.215)差异无统计学意义,2组患者住院天数相当(t=-1.925,P=0.067)。结论HF17与FX80比较,国产滤器威高HF17治疗甲醇中毒的临床效果同样显著,可有效清除血液中的甲醇及其有毒代谢物,纠正酸碱紊乱,缩短住院天数,节约治疗费用。Objective To explore the clinical effect of hemodialysis using the hemodialyzer with a China-made filter(Weigao HF17)and using the hemodialyzer with an imported filter(FX80,Fresenius,Germany)for the treatment of methanol poisoning.Methods A total of 25 patients with methanol poisoning treated with hemodialysis in The Second People's Hospital of Yibin City and The Fifth People's Hospital of Yibin City in March 2022 were selected as the research subjects;9 patients were treated with HF17 hemodialyzer(HF17 group),and 16 patients with FX80 hemodialyzer(FX80 group).Hospitalization days and changes of blood methanol concentration,pH,base excess(BE)and lactate before and after the hemodialysis were compared between the two groups.Results After the treatment,the changes of blood methanol concentration was higher in HF17 group than in FX80 group(t=-3.849,P=0.001);blood pH(FX80 group:t=-6.005,P<0.001;HF17 group:t=-3.501,P=0.008)and methanol concentration(FX80 group:t=11.045,P<0.001;HF17 group:t=13.829,P<0.001)decreased significantly in both groups;blood pH(t=1.461,P=0.158),BE(t=0.760,P=0.455),lactate(t=-1.276,P=0.215),and hospitalization days(t=-1.925,P=0.067)had no statistical significances between the two groups.Conclusion The hemodialyzer equipped with a China-made filter(HF17)and that equipped with an imported filter(FX80)for the treatment of methanol poisoning have the same effects in the clearance of methanol and its toxic metabolites,maintaining acid-base balance,shortening the hospitalization days,and decrease of expenses.

关 键 词：甲醇中毒 滤器 血液透析 

分 类 号：R459.5[医药卫生—治疗学]