银川市社区老年人尿中锌、钴和钼含量与糖尿病的关联性  

Association of the content of zinc,cobalt and molybdenum in urine with diabetes mellitus in community-dwelling elderly individuals in Yinchuan,China

作　　者：王玉华 王瑞 何沛 段思宇 孙健[1,2] WANG Yu-hua;WANG Rui;HE Pei;DUAN Si-yu;Sun Jian(School of Public Health,Ningxia Medical University,Yinchuan,750004,China;Ningxia Key Laboratory of Environmental Factors and Chronic Disease Control;Department of Military Preventive Medicine,Air Force Medical University,Teaching and Research Section of Military Epidemic Prevention and Epidemiology/Key Laboratory of Hazard Assessment and Control in Special Operational Environment of the Ministry of Education)

机构地区：[1]宁夏医科大学公共卫生学院,银川750004 [2]宁夏环境因素与慢性病控制重点实验室 [3]空军军医大学军事预防医学系军队防疫与流行病学教研室、特殊作业环境危害评估与防治教育部重点实验室

出　　处：《环境卫生学杂志》2023年第7期479-484,500,共7页JOURNAL OF ENVIRONMENTAL HYGIENE

基　　金：宁夏回族自治区自然科学基金(2022AAC05028)。

摘　　要：目的明确银川市社区老年人尿中锌、钴和钼的水平,探讨尿中锌、钴和钼的含量与糖尿病患病的关联。方法采用多级抽样方法选择研究对象,通过问卷调查收集研究对象一般人口学信息,通过健康体检对研究对象的血压、血脂、肝功能等指标进行测定,采用电感耦合等离子体质谱测定研究对象尿中锌、钴和钼的浓度,并用尿肌酐校正。根据是否患有糖尿病将研究对象分为病例组和对照组,资料分析使用t检验、非参数检验及卡方检验进行比较分析,参考尿锌、钴和钼的浓度按四分位数分组(Q_(1)-Q_(4)),采用Logistic回归和分层分析,探讨尿中锌、钴和钼含量与糖尿病患病之间的关联及其强度。结果本次共调查1998名社区老年人,糖尿病患者227例(11.36%)。糖尿病组及对照组在年龄、性别、吸烟、饮酒等情况上的差异没有统计学意义,但糖尿病组高血压、高血脂及心脏疾病患者的比例均高于对照组,糖尿病组尿中锌、钴和钼的浓度均高于对照组(P<0.05)。与Q_(1)组相比,尿中锌和钴位于Q_(4)组时糖尿病患病风险的OR(95%CI)分别为4.10(2.56,6.58)和1.61(1.06,2.43),尿中钼位于Q_(3)组时糖尿病患病风险OR(95%CI)为1.53(1.02,2.30)。与Q_(1)组相比,男性尿中锌位于Q_(2)、Q_(3)、Q_(4)组时糖尿病患病风险的OR(95%CI)分别为2.67(1.04,6.86)、4.57(1.86,11.23)和5.17(2.10,12.75);女性尿中锌位于Q_(3)、Q_(4)组时糖尿病患病风险的OR(95%CI)分别为2.36(1.30,4.31)和3.91(2.22,6.87),尿中钴位于Q_(4)组时糖尿病患病风险的OR(95%CI)为2.03(1.14,3.63)。结论社区老年人尿中锌、钴和钼的水平与糖尿病患病风险呈正相关关系,此种关联在女性人群中更加明显。Objective To investigate the content levels of zinc,cobalt,and molybdenum in urine of the elderly individuals at communities of Yinchuan,China,and to explore the association of the contents of zinc,cobalt,and molybdenum in urine with the prevalence of diabetes mellitus.Methods Multilevel sampling method was applied to collect the subjects and a questionnaire survey was used to collect general demographic information,and physical examination was performed to measure the indicators including blood pressure,blood lipids,and liver function.Meanwhile,the mass concentration of zinc,cobalt and molybdenum in the urine were deter-mined by inductively coupled plasma mass spectrometry,with urinary creatinine correction.The subjects were divided into case group and control group according to the presence or absence of diabetes mellitus to perform a descriptive analysis of general demographic in-formation.The data were analyzed by t-test,the non-parametric test,and the chi-square test.The mass concentrations of Zn,Co,and Mo were grouped by quartile,and the Logistic regression analysis and the stratified analysis were used to investigate the association of the contents of zinc,cobalt,and molybdenum in urine with the prevalence of diabetes mellitus and the intensity of such association.Results A total of 1998 community elderly individuals were investigated,among whom there were 227 patients with diabetes mellitus(11.36%).There were no significant differences in age,sex,smoking and drinking between the two groups,but the proportion of pa-tients with hypertension,hyperlipidemia and heart disease in the diabetic group was higher than that in the control group,and the mass concentrations of cobalt,zinc and molybdenum in the urine of the diabetic group were higher than those of the control group,and the differences were statistically significant.Compared with the Q_(1)group,the Q_(4)group in terms of the mass concentrations of urinary zinc and cobalt had odds ratio(OR)and 95%confidential intervals(CI)of 4.10(2.56,6.58)and 1.61(1.06,

关 键 词：金属 锌 钴 钼 糖尿病 老年人 

分 类 号：R122.7[医药卫生—环境卫生学]