气候变化背景下全球常见癌症环境影响因素范围研究进展  

Environmental risk factors for common cancer in a world with climate change:a scoping review

作　　者：张淳 王慧琳 葛龙 李江 李国强[1] ZHANG Chun;WANG Hui-lin;GE Long;LI Jiang;LI Guo-qiang(Key Laboratory of Western China’s Environmental System,College of Earth and Environmental Science,Lanzhou University,Lanzhou 730000,China;Office for Cancer Screening Program in Urban China,Cancer Hospital,Chinese Academy of Medical Sciences,National Cancer Center of China;School of Public Health,Lanzhou University)

机构地区：[1]兰州大学资源环境学院西部环境教育部重点实验室,兰州730000 [2]国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院癌症早诊早治办公室 [3]兰州大学公共卫生学院

出　　处：《环境卫生学杂志》2023年第7期549-558,共10页JOURNAL OF ENVIRONMENTAL HYGIENE

基　　金：北京市科学技术委员会“北京市科技新星计划”(Z201100006820070)。

摘　　要：概述气候变化对发病率居于全球前十位癌种(不包括非黑色素瘤皮肤癌)发病的影响,为后续研究及识别癌症发生相关环境影响因素提供参考。依据《有关范围综述的最新方法指南》,检索PubMed、Web of Science等5个文献数据库,选择符合气候变化与癌症发生相关标准的研究,对已发表的文献进行评价和数据提取。检索时间截止到2021年10月7日。最终纳入的39个研究包括19个原始研究(队列研究等,50%)和20个指南与系统综述(50%)。分布在亚洲、欧洲和北美洲。受气候变化影响的环境因素主要包括四个类别:有毒物质,温度,食品影响、化学物质暴露。环境影响因素受气候变化表征方式的综合影响,如温度变化、海平面上升和极端天气等。影响癌种集中为肝癌、肺癌、结肠癌和胃癌等。全球气候变化可能会进一步提高癌症发病率。目前关于有毒物质方面研究较为深入,尤其是气候变化对黄曲霉毒素影响的研究。同时,如何降低极端温度事件直接对人体健康的危害值得关注。To summarize the impact of climate change on the incidence of the top ten cancers(excluding non-melanoma skin cancer)in the world,and provide reference for follow-up research and identification of cancer risk factors related with environment.According to The latest method ological guidelines on scoping review.Peters,five databases including PubMed and Web of Science were searched for article identification and data extraction,and studies related to climate change and cancer incidence were selected from in-ception to October 7,2021.A total of 39 studies were selected,including 19 original studies such as cohort studies(50%)and 120 guidelines and systematic reviews(50%).These studies were conducted in Asia,Europe,and North America.The environmental fac-tors affected by climate change mainly fell into four categories:toxic substances,temperature,food,and chemical exposure.Environ-mental factors were comprehensively influenced by climate change characterization,such as temperature changes,sea level rise,and extreme weather.The most common cancers were mainly liver cancer,lung cancer,colon cancer,and gastric cancer,etc.Global cli-mate change may further increase cancer incidence.At present,the research on toxic substances is relatively in-depth,especially the research on the impact of climate change on aflatoxins.Meanwhile,how to reduce the direct harm of extreme temperature events to hu-man health deserves attention.

关 键 词：气候变化 环境影响因素 常见癌症 范围综述 

分 类 号：R12[医药卫生—环境卫生学]