糖尿病肾病患者血清铁蛋白和C反应蛋白与营养状况的相关性分析  

Correlation Analysis of Serum Ferritin and C-reactive Protein with Nutritional Status in Diabetic Nephropathy Patients

作　　者：麻馨月 李曼[1] 伊晟[1] 吴雁[1] Ma Xinyue;Li Man;Yi Sheng;Wu Yan(Tianjin Taida Hospital,Tianjin 300457,China)

机构地区：[1]天津市泰达医院,天津300457

出　　处：《医疗装备》2023年第12期78-81,84,共5页Medical Equipment

摘　　要：目的探讨糖尿病肾病(DN)患者血清铁蛋白(SF)、C反应蛋白(CRP)与营养状况的相关性。方法选取2019年1月至2022年4月天津市泰达医院收治的158例DN患者作为试验组,依据临床分期分为早期组(临床分期3期,55例)、中期组(临床分期4期,57例)、晚期组(临床分期5期,46例),另选取同期天津市泰达医院收治的40例未合并肾病的糖尿病患者作为对照组,检测所有研究对象的实验室检查指标[24 h尿蛋白定量(24 h UTP)、血尿素氮(BUN)、血清肌酐(SCr)、甘油三酯(TG)、总胆固醇(TC)、白蛋白(Alb)、血红蛋白(Hb)、SF、CRP]水平并比较;采用Pearson相关性分析SF、CRP与营养状况的相关性。结果试验组24 h UTP、BUN、SCr、TG、TC、SF、CRP水平均高于对照组,Alb、Hb水平均低于对照组,差异有统计学意义(P<0.05)。中、晚期组24 h UTP、BUN、SCr、TG、TC、SF、CRP水平均高于早期组,且晚期组高于中期组,差异有统计学意义(P<0.05)。中、晚期组Alb、Hb水平均低于早期组,且晚期组低于中期组,差异有统计学意义(P<0.05)。Pearson相关性分析显示,SF、CRP与Alb、Hb呈负相关(P<0.05),与TC呈正相关(P<0.05),与TG无关,且SF与CRP呈正相关(P<0.05)。结论DN患者SF、CRP与营养状况具有相关性,临床可通过检测SF、CRP评估DN患者的营养状况,并据此为治疗、预后提供参考。Objective The correlation between serum ferritin(SF),C-reactive protein(CRP)and nutritional status in diabetic nephropathy(DN)patients was investigated.Methods With selection of 158 DN patients admitted to Tianjin Taida Hospital from January 2019 to April 2022 as the observation group,they were divided into the early group(clinical stage 3,55 cases),the mid-term group(clinical stage 4,57 cases),and the late group(clinical stage 5,46 cases),based on clinical stage.In addition,40 diabetes patients without DN admitted to Tianjin Taida Hospital in the same period were selected as the control group.The laboratory examination indicators[24-hour urinary tot protein quantity(24-hour UTP),blood urea nitrogen(BUN),serum creatinine(SCr),triglycerides(TG),total cholesterol(TC),albumin(Alb),hemoglobin(Hb),SF,CRP]levels of all study subjects were detected and compared;Pearson correlation analysis was used to investigate the correlation between SF,CRP,and nutritional status.Results The levels of 24-hour UTP,BUN,SCr,TG,TC,SF,CRP in the observation group were higher than those in the control group,while the levels of Alb and Hb were lower than those in the control group,with statistically significant differences(P<0.05).The levels of 24-hour UTP,BUN,SCr,TG,TC,SF,and CRP in the mid and late stage groups were higher than those in the early stage group,and the late stage group was higher than the mid stage group,with statistically significant differences(P<0.05).The levels of Alb and Hb in the mid and late stage groups were lower than those in the early stage group,and the late stage group was lower than the mid stage group,with statistically significant differences(P<0.05).Pearson correlation analysis showed that SF and CRP were negatively correlated with Alb and Hb(P<0.05),positively correlated with TC(P<0.05),and not related to TG.Moreover,SF was positively correlated with CRP(P<0.05).Conclusion There are correlations between SF and CRP levels in DN patients and their nutritional status.Clinical evaluation of the nutritional stat

关 键 词：糖尿病肾病 铁蛋白 C反应蛋白 营养状况 相关性 

分 类 号：R587.2[医药卫生—内分泌]