血清sFlt-1、PLGF、sFlt-1/PLGF值与子痫前期的关系及结合PI、MAP检测对子痫前期的预测价值  

Relationship between serum sFlt⁃1,PLGF,sFlt⁃1/PLGF and preeclampsia,and the predictive value of combined PI and MAP detection in pregnant women with preeclampsia

作　　者：孙红梅 何花 詹学婷 姚栋琴 SUN Hongmei;HE Hua;ZHAN Xueting;YAO Dongqin(Xuancheng People's Hospital,Xuancheng,Anhui,China,242000)

机构地区：[1]宣城市人民医院,安徽宣城242000

出　　处：《分子诊断与治疗杂志》2023年第6期955-959,共5页Journal of Molecular Diagnostics and Therapy

基　　金：安徽省自然科学基金面上项目(2020085MH10219)。

摘　　要：目的分析血清可溶性血管内皮生长因子受体-1(sFlt-1)、胎盘生长因子(PLGF)、sFlt-1/PLGF比值与子痫前期(PE)的关系及结合子宫动脉搏动指数(PI)、平均动脉压(MAP)对子痫前期的预测效果。方法选取2021年1月至2022年12月宣城市人民医院收治的301例孕妇的临床资料,根据是否可能发展为PE及PE严重程度不同将孕妇分为A组(正常妊娠孕妇,n=272)、B组(PE不伴严重症状孕妇,n=12)及C组(重度PE孕妇,n=17),比较三组在孕早、中、晚三个阶段的sFlt-1、PLGF、PI、MAP及sFlt-1/PLGF值,采用Logistic回归分析各阶段MAP、sFlt-1/PLGF及PI与PE之间的关系,采用ROC曲线评估MAP、s Flt-1/PLGF及PI对孕妇PE的预测价值。结果孕早、中、晚三个阶段sFlt-1中位数倍数(MoM值)比较:C组>B组>A组,孕早、中、晚三个阶段PLGF比较:A组>B组>C组,孕中、晚期PI比较:C组>B组>A组,孕晚期MAP比较:C组>B组>A组,差异均有统计学意义(P<0.05)。孕早期的sFlt-1/PLGF比值、孕中期的s Flt-1/PLGF及PI、孕晚期的MAP、sFlt-1/PLGF及PI是影响PE发生的独立危险因素(P<0.05)。孕晚期MAP、sFlt-1/PLGF、PI及三者联合诊断PE的AUC分别为0.678、0.771、0.711和0.906。结论MAP及PI、sFlt-1/PLGF比值与PE的发生密切相关,三者指标联合检测在预测孕早、中、晚期PE发病中具有较高的应用价值。Objective To analyze the relationship between serum soluble vascular endothelial growth factor receptor⁃1(sFlt⁃1),placental growth factor(PLGF)levels,sFlt⁃1/PLGF ratio and preeclampsia(PE),and the predictive effect of the combination of uterine artery beating index(PI)and mean arterial pres⁃sure(MAP)on preeclampsia in pregnant women.Methods Clinical data of pregnant women admitted to Xu⁃anxeng People's Hospital from January 2021 to December 2022 were selected,and the pregnant women were di⁃vided into group A(normal pregnant women,n=272),group B(pregnant women without severe symptoms of PE,n=12)and group C(pregnant women with severe PE,n=17)according to the possibility of developing PE and the severity of PE,the sFlt⁃1,PLGF,PI,MAP and sFlt⁃1/PLGF in the three groups of pregnant women in the early,middle and late stages of pregnancy were compared,Logistic regression was used to analyze the rela⁃tionship between MAP,sFlt⁃1/PLGF and PI and PE at each stage,and the ROC curve was used to evaluate the predictive value of MAP,sFlt⁃1/PLGF and PI on PE in pregnant women.Results Comparison of sFlt⁃1 medi⁃an multiples(MoM value)in the early,middle and late stages of pregnancy:group C>group B>group A,comparison of PLGF in the three stages of early pregnancy,middle and late pregnancy:group A>group B>group C.The comparison of PI in the middle and late pregnancy:group C>group B>group A,the comparison of MAP in the third trimester:group C>group B>group A,the differences were statistically significant(P<0.05).The sFlt⁃1/PLGF ratio in the first trimester,sFlt⁃1/PLGF and PI in the second trimester,MAP,sFlt⁃1/PLGF and PI in the third trimester were independent risk factors for PE(P<0.05).The AUCs of MAP,sFlt⁃1/PLGF,PI and their combined diagnosis of PE in the third trimester of pregnancy were 0.678,0.771,0.711 and 0.906,respectively.Conclusion MAP,PI and sFlt⁃1/PLGF ratio are closely related to the occurrence of PE,and the combined detection of the three indicators has high application value in pre

关 键 词：SFLT-1 PLGF 子痫前期 PI 

分 类 号：R714.244[医药卫生—妇产科学]