双向骨搬移联合对合端植骨内固定治疗胫骨骨折效果及对PDGF、bFGF及TGF-β水平的影响  

Effect of bidirectional bone displacement combined with bone grafting and internal fixation on the levels of PDGF,bFGF and TGF⁃βfor tibial fractures

作　　者：徐辉 丁燕华 李美 张冲 XU Hui;DING Yanhua;LI Mei;ZHANG Chong(Department of Orthopedics,Haimen District People's Hospital,Nantong,Jiangsu,China,226100)

机构地区：[1]南通市海门区人民医院骨科,江苏南通226100

出　　处：《分子诊断与治疗杂志》2023年第6期1051-1054,1059,共5页Journal of Molecular Diagnostics and Therapy

基　　金：南通市科技计划项目(MSZ21111)。

摘　　要：目的探讨双向骨搬移联合对合端植骨内固定治疗胫骨骨折效果及对PDGF、bFGF及TGF-β水平的影响。方法选取2018年3月至2022年3月期间南通市海门区人民医院收治的开放性胫骨骨折伴大段骨缺损的患者102例为研究对象,所有患者均接受手术治疗,按照患者不同治疗意愿分为实验组(lizard技术双向骨搬移联合对合端植骨内固定治疗,n=52)和对照组(lizard技术双向骨搬移治疗,n=50)。对比两组治疗后骨愈合情况及下肢功能,对比两组治疗前后C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、血小板衍生生长因子(PDGF)、碱性成纤维细胞生长因子(bFGF)及转化生长因子-β(TGF-β),对比两组治疗后并发症发生情况。结果实验组骨愈合、下肢功能优良率分别为98.07%、96.15%,高于对照组的78.00%、76.00%,差异具有统计学意义(P<0.05)。实验组治疗后CRP、TNF-α及IL-6水平低于对照组,差异具有统计学意义(P<0.05)。实验组治疗后PDGF、bFGF、TGF-β水平高于对照组,差异具有统计学意义(P<0.05)。治疗后,实验组并发症总人数占比低于对照组,差异具有统计学意义(P<0.05)。结论采用lizarov技术双向骨搬移联合对合端植骨内固定治疗开放性胫骨骨折伴大段骨缺损患者,能提高临床治疗效果,改善炎性因子、PDGF、bFGF及TGF-β水平,降低并发症的发生率,具有临床推广价值。Objective To explore the effects of bidirectional bone displacement combined with bone grafting and internal fixation on the levels of PDGF,bFGF and TGF⁃βfor tibial fractures.Methods 102 patients with open tibial fractures and large bone defects admitted to Haimen District People's Hospital of Nantong City from March 2018 to March 2022 were selected as the research objects,all patients received surgical treatment,and according to the different treatment wishes of patients,they were divided into the experimental group(lizard technology two⁃way bone transfer combined with internal fixation of occlusal bone graft,n=52)and the control group(lizard technology two⁃way bone transfer therapy,n=50).Bone healing and lower limb function after treat⁃ment were compared between the two groups,C⁃reactive protein(CRP),Tumor Necrosis Factor(TNF⁃α),inter⁃leukin⁃6(IL⁃6),platelet⁃derived growth factor(PDGF),basic fibroblast growth factor(bFGF)and transforming growth factor⁃β(TGF⁃β)before and after treatment were compared between the two groups,the incidence of com⁃plications after treatment was compared between the two groups.Results The excellent and good rates of bone healing and lower limb function in the experimental group were 98.07%and 96.15%,respectively,higher than those in the control group(78.00%and 76.00%),with statistically significant differences(P<0.05).After treatment,the levels of CRP,TNF⁃αand IL⁃6 in the experimental group were lower than those in the control group,and the difference was statistically significant(P<0.05).The levels of PDGF,bFGF,and TGF⁃βin the experi⁃mental group were higher than those in the control group,with statistical significance(P<0.05).After treatment,the proportion of total complications in the experimental group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The use of lizarov technique for bidirectional bone transfer combined with bone graft internal fixation in the treatment of open tibi

关 键 词：胫骨骨折伴大段骨缺损 lizarov技术双向骨搬移联合对合端植骨内固定 

分 类 号：R687.3[医药卫生—骨科学]