头孢哌酮钠舒巴坦钠致凝血功能异常危险因素的Meta分析  

Risk Factors for Cefoperazone Sodium-Sulbactam sodium-Induced Blood Coagulation Disorders:A Meta-Analysis

作　　者：郝玉佩 于静[1] 刘琰 李彦明[1] 王婧[1] HAO Yupei;YU Jing;LIU Yan;LI Yanming;WANG Jing(The First Hospital of Hebei Medical University,Shijiazhuang,Hebei,China 050031)

机构地区：[1]河北医科大学第一医院,河北石家庄050031

出　　处：《中国药业》2023年第13期112-117,共6页China Pharmaceuticals

基　　金：河北省卫生健康委员会医学科学研究课题[20201171,20231085]。

摘　　要：目的分析影响头孢哌酮钠舒巴坦钠致凝血功能异常的危险因素。方法计算机检索中国知网(CNKI)、万方(WanFang)、维普(VIP)数据库、中国生物医学文献数据库(CBM)及PubMed,The Cochrane Library,Embase,Web of Science中有关评估头孢哌酮钠舒巴坦钠致凝血功能异常患者的危险因素的随机对照试验(RCT),检索时限为自建库起至2022年5月18日。采用卡斯尔-渥太华量表(NOS)对纳入研究进行质量评价,提取有效数据,并采用RevMan 5.3软件进行Meta分析。结果最终纳入6篇中文病例RCT,涉及患者733例,其中观察组258例,对照组475例。Meta分析结果显示,头孢哌酮钠舒巴坦钠致凝血功能异常的可能危险因素为合并肝功能不全[OR=13.84,95%CI(5.23,36.62),P<0.00001],合并肾功能不全[OR=6.73,95%CI(3.09,14.69),P<0.00001],饮食情况[OR=4.58,95%CI(2.13,9.83),P<0.0001],给药剂量[OR=7.13,95%CI(2.05,24.84),P=0.002],营养情况[OR=4.21,95%CI(1,83,9.67),P=0.0007]。结论合并肝、肾功能不全,饮食减少,给药剂量偏高,营养不良是头孢哌酮钠舒巴坦钠致凝血功能异常的可能危险因素,建议用药过程中密切监测存在危险因素患者的凝血指标。Objective To analyze the risk factors for cefoperazone sodium-sulbactam(CPZ-SBT)sodium-induced blood coagulation disorders.Methods The studies related to the randomized controlled trial(RCTs)of risk factors for CPZ-SBT-induced blood coagulation disorders in databases such as CNKI,WanFang,VIP,CBM,PubMed,The Cochrane Library,Embase,and Web of Science were searched from the inception to May 18,2022.The quality evaluation of the included studies was conducted by the Castle-Ottawa Scale(NOS)to extract valid data,and Meta-analysis was conducted by the Rev Man 5.3 software.Results Six Chinese studies of RCTs were selected,with a total of 733 cases,including 258 cases in the observation group and 475 cases in the control group.Meta-analysis showed that the risk factors for CPZ-SBT-induced blood coagulation disorders were hepatic insufficiency[OR=13.84,95%CI(5.23,36.62),P<0.00001],renal insufficiency[OR=6.73,95%CI(3.09,14.69),P<0.00001],dietary status[OR=4.58,95%CI(2.13,9.83),P<0.0001],medication dosage[OR=7.13,95%CI(2.05,24.84),P=0.002],and nourishment[OR=4.21,95%CI(1.83,9.67),P=0.0007].Conclusion Combination with hepatic insufficiency and renal insufficiency,reduced diet,high dosage,and malnutrition were the possible risk factors for CPZ-SBT-induced blood coagulation disorders.It is suggested that the coagulation-related indicators of patients with risk factors should be closely monitored during the medication.

关 键 词：头孢哌酮钠舒巴坦钠 凝血功能 危险因素 META分析 系统评价 

分 类 号：R969.3[医药卫生—药理学] R978.1[医药卫生—药学]