活血化瘀药在冠脉微血管功能障碍治疗中的运用规律  

Application rules of Huoxue Huayu in coronary microvascular dysfunction

作　　者：苏殷婷 陈兆善[1] 赖志昆 SU Yinting;CHEN Zhaoshan;LAI Zhikun(Shanghai Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200071,China)

机构地区：[1]上海中医药大学附属市中医医院,上海200071

出　　处：《陕西中医》2023年第7期961-964,共4页Shaanxi Journal of Traditional Chinese Medicine

基　　金：上海市卫生健康委员会临床医学专项课题(20204Y0260)。

摘　　要：冠脉微血管功能障碍的发病率逐年上升,已成为严重危害中老年患者的常见心血管疾病。现代医学在一定程度上能够改善冠脉微循环,增加冠脉灌注,减轻心肌缺血症状。由于冠脉微血管结构性、功能性障碍相互交错的复杂关系,治疗上缺乏有效的靶向药物。中医活血化瘀药治疗冠脉微血管功能障碍疗效较好,通过合理配伍和安全施用可充分发挥益气活血、行气活血、化痰祛瘀功效,发挥抑制血小板聚集、抗炎、缓解冠脉微血管痉挛、增加冠脉血流储备及改善心绞痛症状等作用。本研究着重对活血化瘀药治疗冠脉微血管功能障碍的临床应用及常用配伍、中西医结合治疗机制等进行探讨,为临床应用提供参考。The incidence of coronary microvascular dysfunction(CMVD)is increasing year by year.CMVD is a common clinical cardiovascular disease,especially among middle-aged and elderly patients.Modern medicine can improve coronary microcirculation and increase coronary perfusion,in order to reduce myocardial ischemia.Due to complex relationship between structural and functional dysfunctions of coronary microvascular disease,effective targeted drugs are lacking.Huoxue Huayu have significant effect on CMVD and have certain characteristics in clinical application.Through reasonable compatibility and safe use,can fully play the role of Yiqi Huoxue,Xingqi Huoxue,Huatan Quyu to inhibit paltelet aggregation,anti-inflammatory,relieve coronary microvascular spasm,increase coronary flow reserve and improve anginal symptoms.Discuss clinical application,commonly used compatibility and mechanism of integrated Chinese and western medicine in the treatment of CMVD.

关 键 词：冠脉微血管功能障碍 活血化瘀 益气活血 行气活血 化痰祛瘀 

分 类 号：R543.3[医药卫生—心血管疾病]