西地那非联合高频振荡通气在新生儿持续肺动脉高压治疗中的安全性及有效性分析  

Safety and efficacy analysis of sildenafil combined with high-frequency oscillatory ventilation in the treatment of persistent pulmonary hypertension in neonates

作　　者：徐荣晶 段正艳 王静春 XU Rongjing;DUAN Zhengyan;WANG Jingchun(Department of Pediatrics,First People's Hospital of Dali,Dali,Yunnan,671000,China)

机构地区：[1]大理市第一人民医院儿科,云南大理671000

出　　处：《当代医学》2022年第30期8-11,共4页Contemporary Medicine

摘　　要：目的探讨西地那非联合高频振荡通气治疗新生儿持续肺动脉高压的安全性及有效性。方法选取2019年1月至2020年6月本院收治的60例新生儿持续肺动脉高压患儿作为研究对象,通过盲盒抽取编号的方式分为研究组和对照组,每组30例。对照组采取高频振荡通气治疗,研究组采取西地那非联合高频振荡通气治疗,比较两组临床疗效、肺动脉收缩压(SPAP)、左上肢体循环收缩压(SBP)、血气分析指标水平及不良反应发生情况。结果研究组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前,两组SPAP、左上肢体循环SBP比较差异无统计学意义;治疗后,研究组SPAP低于对照组,差异统计学意义(P<0.05),两组治疗前后左上肢体循环SBP比较差异无统计学意义。治疗前,两组动脉血二氧化碳分压(PaCO_(2))、吸入氧浓度分数(FiO_(2))、动脉血氧饱和度(SaO_(2))、动脉血氧分压(PaO_(2))水平比较差异无统计学意义;治疗后,两组PaCO_(2)、FiO_(2)水平均低于治疗前,SaO_(2)、PaO_(2)水平均高于治疗前,且研究组PaCO_(2)、FiO_(2)水平均低于对照组,SaO_(2)、PaO_(2)水平均高于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论西地那非联合高频振荡通气治疗新生儿持续肺动脉高压疗效确切,可改善患儿肺动脉压及血气分析指标,且具有较高的安全性,值得临床推广应用。Objective To investigate the safety and efficacy of sildenafil combined with high-frequency oscillatory ventilation in the treatment of persistent pulmonary hypertension in neonates.Methods A total of 60 children with persistent pulmonary hypertension admitted to our hospital from January 2019 to June 2020 were selected as the research subjects,and they were divided into study group and control group according to blind box group number,with 30 cases in each group.The control group was treated with high-frequency oscillatory ventilation,and the study group was treatdoied with sildenafil combined with high-frequency oscillatory ventilation,the clinical efficacy,systolic pulmonary artery pressure(SPAP),left upper limb circulation systolic blood pressure(SBP),blood gas analysis index level and occurrence of adverse reactions were compared between the two groups.Results The total effective rate of treatment in the study group was higher than that in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in SPAP and left upper limb circulation SBP between the two groups;after treatment,the SPAP in the study group was lower than that in the control group,and the difference was statistically significant(P<0.05),and there was no significant difference in the left upper limb circulation SBP between the two groups before and after treatment.Before treatment,there were no significant differences in arterial arterial blood carbon dioxide partial pressure(PaCO_(2)),fraction of inspiration oxygen(FiO_(2)),arterial oxygen saturation(SaO_(2)),and arterial oxygen partial pressure(PaO_(2));after treatment,the levels of PaCO_(2)and FiO_(2)in the two groups were lower than before treatment,the levels of SaO_(2)and PaO_(2)in the two groups were higher than before treatment,the levels of PaCO_(2)and FiO_(2)in the study group were lower than those in the control group,and the levels of SaO_(2)and PaO_(2)in the study group were higher than those in the control group

关 键 词：西地那非 高频振荡通气 新生儿持续肺动脉高压 肺动脉压 体循环收缩压 血气分析 

分 类 号：R722.1[医药卫生—儿科]