咪达唑仑在小儿惊厥持续状态治疗中的应用方法与疗效  

Application and efficacy of midazolam in the treatment of persistent convulsion in children

作　　者：彭晨娜 张彬伟 赵静 PENG Chenna;ZHANG Binwei;ZHAO Jing(Department of Neurology,Wuxi Eighth People's Hospital,Wuxi,Jiangsu,214000,China)

机构地区：[1]无锡市第八人民医院神经内科,江苏无锡214000

出　　处：《当代医学》2022年第35期92-94,共3页Contemporary Medicine

摘　　要：目的探讨咪达唑仑在小儿惊厥持续状态治疗中的应用方法与疗效。方法选取2015年7月至2021年7月本院收治的60例小儿惊厥持续状态患儿作为研究对象,随机分为一般组和实验组,每组30例。一般组采用地西泮治疗,实验组采用咪达唑仑治疗。比较两组体征变化、临床疗效、惊厥消失时间、不良反应发生情况。结果用药前,两组平均动脉压、心率比较差异无统计学意义;用药后,平均动脉压、心率均高于一般组,差异有统计学意义(P<0.05)。实验组治疗总有效率为100.00%,高于一般组的86.67%,差异有统计学意义(P<0.05)。实验组惊厥消失时间为(19.74±4.66)h,短于一般组的(28.30±5.17)h,差异有统计学意义(P<0.05)。实验组不良反应发生率为3.33%,低于一般组的23.33%,差异有统计学意义(P<0.05)。结论咪达唑仑治疗小儿惊厥持续状态疗效显著,可加速惊厥消失,减少呼吸抑制,降低不良反应发生风险,稳定患儿体征,值得临床推广应用。Objective To investigate the application and effect of midazolam in the treatment of children with persistent convulsion.Methods A total of 60 children with persistent convulsion treated in our hospital from July 2015 to July 2021 were selected as research subjects,and they were randomly divided into general group and experimental group,with 30 cases in each group.The general group was treated with diazepam and the experimental group with midazolam.The changes of physical signs,clinical efficacy,disappearance time of convulsion and occurrence of adverse reactions were compared between the two groups.Results Before medication,there was no significant difference in mean arterial pressure and heart rate between the two groups;after medication,the mean arterial pressure and heart rate were higher than those in the general group,and the differences were statistically significant(P<0.05).The total effective rate of the experimental group was 100.00%,higher than 86.67% in the general group,and the difference was statistically significant(P<0.05).The disappearance time of convulsion in the experimental group was(19.74±4.66)h,which was shorter than(28.30±5.17)h in the general group,the difference was statistically significant(P<0.05).The incidence of adverse reactions in the experimental group was 3.33%,lower than 23.33% in the general group,and the difference was statistically significant(P<0.05).Conclusion Midazolam has significant curative effect in the treatment of persistent state of convulsion in children,which can accelerate the disappearance of convulsion,reduce respiratory depression,reduce the risk of adverse reactions,and stabilize the physical signs of children,which is worthy of clinical application.

关 键 词：咪达唑仑 临床疗效 体征变化 惊厥持续状态 

分 类 号：R720.597[医药卫生—急诊医学]