格列吡嗪联合二甲双胍治疗老年2型糖尿病的临床疗效  

Clinical efficacy of glipizide combined with metformin in the treatment of elderly type 2 diabetes mellitus

作　　者：黄东明[1] HUNAG Dongming(Department of General Internal Medicine,People's Hospital of Boluo County,Huizhou,Guangdong,516100,China)

机构地区：[1]博罗县人民医院普通内科,广东惠州516100

出　　处：《当代医学》2022年第27期75-77,共3页Contemporary Medicine

摘　　要：目的探究格列吡嗪联合二甲双胍治疗老年2型糖尿病(T2DM)的临床疗效。方法选取2018年3月至2021年3月本院收治的150例老年T2DM患者作为研究对象,根据治疗方案不同分为常规组与联合组,各75例。常规组给予格列吡嗪治疗,联合组给予格列吡嗪联合二甲双胍治疗,比较两组治疗前后血糖水平[空腹血糖(FBG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbAlc)]、日间血糖水平波动指数[24 h平均血糖波动幅度(MAGE)、日间血糖平均绝对差(MODD)]及不良反应发生情况。结果治疗前,两组FBG、2 h PG及HbAlc水平比较差异无统计学意义;治疗后,联合组FBG、2 h PG及HbAlc水平均明显低于常规组,差异有统计学意义(P<0.05)。治疗前,两组MAGE、MODD水平比较差异无统计学意义;治疗后,联合组MAGE和MODD水平均明显低于常规组,差异有统计学意义(P<0.05)。联合组不良反应发生率为2.67%,明显低于常规组的12.00%,差异有统计学意义(P<0.05)。结论格列吡嗪联合二甲双胍联合治疗老年T2DM疗效显著,可有效控制患者的血糖水平,且安全性高,值得临床推广应用。Objective To investigate the clinical efficacy of glipizide combined with metformin in the treatment of elderly type 2 diabetes mellitus(T2DM).Methods A total of 150 elderly patients with T2DM who were treated in our hospital from March 2018 to March 2021 were selected as the research subjects,and they were divided into the conventional group and the combined group according to the differences treatment plan,with 75 cases in each group.The conventional group was treated with glipizide,and the combined group was treated with glipizide combined with metformin.The blood glucose levels(fasting blood glucose[FBG],2 h postprandial blood glucose[2 h PG],glycated hemoglobin[HbAlc]),daytime blood glucose level fluctuations index(24 h mean amplitude of glycemic excursions[MAGE],mean of daily differences[MODD])before and after treatment,and adverse reactions were compared between the two groups.Results Before treatment,there was no significant difference in the levels of FBG,2 h PG and HbAlc between the two groups;after treatment,the levels of FBG,2 h PG and HbAlc in the combined group were significantly lower than those in the conventional group,and the differences were statistically significant(P<0.05).Before treatment,there was no significant difference in the levels of MAGE and MODD between the two groups;after treatment,the levels of MAGE and MODD in the combined group were significantly lower than those in the conventional group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in the combined group was 2.67%,which was significantly lower than 12.00%in the conventional group,and the difference was statistically significant(P<0.05).Conclusion Glipizide combined with metformin in the treatment of elderly T2DM has significant efficacy,can effectively control the blood sugar level of patients,and has high safety,which is worthy of clinical application.

关 键 词：老年2型糖尿病 格列吡嗪 二甲双胍 联合用药 血糖水平 不良反应 

分 类 号：R587.1[医药卫生—内分泌]