纳洛酮联合门冬氨酸鸟氨酸治疗急性酒精中毒的临床疗效  

Clinical efficacy of naloxone combined with ornithine aspartate in the treatment of acute alcoholism

作　　者：张冈毅 蔡凯[1] 岳红梅 李绍清[1] 邓素贞 ZHANG Gangyi;CAI Kai;YUE Hongmei;LI Shaoqing;DENG Suzhen(Department of General Practice,the Sixth Affiliated Hospital of Guangzhou Medical University/Qingyuan People's Hospital,Qingyuan,Guangdong,511500,China)

机构地区：[1]广州医科大学附属第六医院/清远市人民医院全科医学,广东清远511500

出　　处：《当代医学》2022年第27期125-127,共3页Contemporary Medicine

摘　　要：目的探究纳洛酮联合门冬氨酸鸟氨酸治疗急性酒精中毒的临床疗效。方法选取2017年1月至2020年1月于本院治疗的94例急性酒精中毒患者作为研究对象,根据随机抽签法分为常规组和实验组,每组47例。常规组给予静脉滴注纳洛酮治疗,实验组在常规组基础上联合门冬氨酸鸟氨酸治疗。比较两组临床疗效、症状消失时间和完全清醒时间(昏迷期、共济失调期、兴奋期)、肝功能指标[丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)]及不良反应发生情况。结果实验组治疗总有效率为95.74%,高于常规组的76.60%,差异有统计学意义(P<0.05)。实验组昏迷期、共济失调期、兴奋期临床症状消失时间和完全清醒时间均短于常规组,差异有统计学意义(P<0.05)。治疗后,实验组AST、ALT水平均低于常规组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论纳洛酮联合门冬氨酸鸟氨酸治疗急性酒精中毒疗效显著,可缩短患者昏迷期、共济失调期、兴奋期临床症状消失时间和完全清醒的时间,改善肝功能,安全性较高,值得临床推广应用。Objective To explore the clinical efficacy of naloxone combined with ornithine aspartate in the treatment of acute alcoholism.Methods 94 patients with acute alcoholism who were treated in our hospital from January 2017 to January 2020 were selected as the research subjects,and they were divided into the routine group and the experimental group according to lottery,with 47 cases in each group.The routine group was treated with intravenous infusion of naloxone,and the experimental group was treated with ornithine aspartate on the basis of the routine group.The clinical efficacy,symptom disappearance time,full awake time(coma phase,ataxia phase,excited phase),liver function indexes(alanine aminotransferase[ALT],aspartate aminotransferase[AST])and adverse reactions were compared between the two groups.Results The total effective rate of treatment in the experimental group was 95.74%,which was higher than 76.60%in the routine group,and the difference was statistically significant(P<0.05).The symptom disappearance time,full awake time in the experimental group during coma,ataxia and excitement were shorter than those in the routine group,and the differences were statistically significant(P<0.05).After treatment,the levels of AST and ALT in the experimental group were lower than those in the routine group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups.Conclusion Naloxone combined with ornithine aspartate has significant effect in the treatment of acute alcoholism,and can shorten symptom disappearance time,full awake time in patients with coma,ataxia and excitement,and improve liver function,has high safety,which is worthy of clinical promotion.

关 键 词：纳洛酮 门冬氨酸鸟氨酸 急性酒精中毒 临床疗效 

分 类 号：R595.6[医药卫生—内科学]