经皮冠脉介入术治疗冠状动脉粥样硬化性心脏病伴左心功能不全患者的临床疗效  

Clinical efficacy of percutaneous coronary intervention in the treatment of patients with coronary atherosclerotic heart disease and left ventricular insufficiency

作　　者：范旭岚 FAN Xulan(The Second Department of Cardiology,the Fourth People's Hospital of Shenyang,Shenyang,Liaoning,110031,China)

机构地区：[1]沈阳市第四人民医院心内二科,辽宁沈阳110031

出　　处：《当代医学》2022年第27期159-162,共4页Contemporary Medicine

摘　　要：目的探讨经皮冠脉介入术(PCI)治疗冠状动脉粥样硬化性心脏病(冠心病)伴左心功能不全患者的临床疗效。方法选取2017年1月至2019年12月本院收治的100例冠心病伴左心功能不全患者作为研究对象,按照随机数字表法分为两组,各50例。对照组给予常规药物治疗,观察组给予PCI治疗。比较两组心功能指标[左心室舒张末期内径(LVEDD)、左心室射血分数(LVEF)、左心室收缩末期内径(LVESD)]、纤溶活性指标[纤溶酶原激活物抑制剂-1(PAI-1)、组织型纤溶酶原激活物(tPA)]、6 min步行距离及心血管不良事件发生情况。结果治疗后,观察组LVEDD、LVESD均短于对照组,LVEF高于对照组,差异有统计学意义(P<0.05)。治疗后,观察组PAI-1水平低于对照组,tPA水平高于对照组,6 min步行距离长于对照组,差异有统计学意义(P<0.05)。两组心血管不良事件发生率比较差异无统计学意义。结论PCI治疗冠心病伴左心功能不全患者疗效显著,可改善其心功能,调节机体纤溶活性指标,减少心血管不良事件的发生,值得临床推广应用。Objective To investigate the clinical efficacy of percutaneous coronary intervention(PCI)in the treatment of patients with coronary atherosclerotic heart disease(coronary heart disease)and left ventricular insufficiency.Methods 100 patients with coronary heart disease and left ventricular insufficiency admitted to our hospital from January 2017 to December 2019 were selected as the research subjects,and they were divided into two groups according to the random number table method,with 50 cases in each group.The control group was given routine drug treatment,and the observation group was given PCI treatment.The cardiac function indexes(left ventricular end-diastolic diameter[LVEDD],left ventricular ejection fraction[LVEF],left ventricular end-systolic diameter[LVESD]),and fibrinolytic activity indexes(plasminogen activator inhibitor-1[PAI-1],tissue-type plasminogen activator[tPA]),6 min walking distance and incidence of adverse cardiovascular events were compared between the two groups.Results The LVEDD and LVESD in the observation group were shorter than those in the control group,and the LVEF in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the level of PAI-1 in the observation group was lower than that in the control group,the level of tPA was higher than that in the control group,and the 6 min walking distance was longer than that in the control group,and the difference was statistically significant(P<0.05).There was no significant difference in the incidence of cardiovascular adverse events between the two groups.Conclusion PCI has significant curative effect in the treatment of patients with coronary heart disease and left ventricular insufficiency,which can improves cardiac function,regulates fibrinolytic activity index,and reduces the occurrence of adverse cardiovascular events,which is worthy of clinical promotion and application.

关 键 词：冠状动脉粥样硬化性心脏病 左心功能不全 经皮冠脉介入术 纤溶活性 

分 类 号：R541.4[医药卫生—心血管疾病]