孕晚期女性生殖道感染状况及药敏调查分析  

Investigation and analysis of female reproductive tract infection and drug susceptibility in late pregnancy

作　　者：高爽[1] 孙晓娟[1] 李康怡 GAO Shuang;SUN Xiaojuan;LI Kangyi(Department of Clinical Diagnostic Laboratory,ShenyangWomen's and Children's Hospital,Shenyang,Liaoning,110011,China)

机构地区：[1]沈阳市妇婴医院检验科,辽宁沈阳110011

出　　处：《当代医学》2022年第28期11-15,共5页Contemporary Medicine

基　　金：辽宁省自然科学基金项目(20170540839)。

摘　　要：目的探讨本地区孕晚期女性生殖道感染状况及其药敏分析,为临床诊疗提供科学依据。方法选取2018年12月至2019年11月本地区16499例孕晚期女性作为研究对象,采集所有研究对象的生殖道分泌物进行细菌鉴定和药物敏感试验,分析孕晚期女性生殖道感染情况和耐药状况。结果16499份送检标本共检出3034株病原菌,其中白色假丝酵母菌最多,共1517株,占比50.00%;B群链球菌(GBS)472株,占比15.56%;都柏林假丝酵母菌432株,占比14.24%;光滑假丝酵母菌409株,占比13.48%;妊娠女性GBS携带率为2.86%。GBS对红霉素、克林霉素、左氧氟沙星耐药率较高,未检测到对青霉素、氨苄西林、头孢曲松、美罗培南、万古霉素和利奈唑胺的耐药株。真菌对氟胞嘧啶和两性霉素B的灵敏度较高,对伊曲康唑的耐药率较高。结论本地区孕晚期女性生殖道病原体呈多元化分布趋势,以真菌为主,GBS居于革兰氏阳性菌感染的首位。临床上需加强监测孕晚期女性生殖道感染情况,尽早干预,合理应用抗生素,尽可能避免母婴不良妊娠结局。Objective To investigate the status of female genital tract infection and its drug susceptibility analysis in the third trimester of pregnancy in this region,and to provide scientific basis for clinical diagnosis and treatment.Methods 16499 women in the third trimester of pregnancy from December 2018 to November 2019 were selected as the study subjects,and the genital tract secretions of all the subjects were collected for bacterial identification and drug susceptibility tests,and the genital tract infection and drug resistance status of women in the third trimester were analyzed.Results A total of 3034 pathogenic bacteria were detected in 16499 specimens,of which Candida albicans was the most,with a total of 1517 strains,accounting for 50.00%;472 strains of group B streptococcus(GBS),accounting for 15.56%;432 strains of Candida dublin,accounting for 14.24%;there were 409 strains of Candida glabre,accounting for 13.48%;the GBS carrying rate of pregnant women was 2.86%.GBS had high resistance rate to erythromycin,clindamycin,and levofloxacin,and no resistant strains to penicillin,ampicillin,ceftriaxone,meropenem,vancomycin,and linezolid were detected.The fungus has high sensitivity to flucytosine and amphotericin B,and high resistance to itraconazole.Conclusion The distribution of female genital tract pathogens in the third trimester of pregnancy in this region is diversified,mainly fungi,and GBS ranks first among bacterial infections.It is necessary to strengthen the monitoring of female genital tract infection in the third trimester,intervene as soon as possible,rationally use antibiotics,and avoid adverse maternal and infant pregnancy outcomes as much as possible.

关 键 词：生殖道感染 耐药性 孕晚期女性 

分 类 号：R711[医药卫生—妇产科学]