布地奈德混悬液雾化吸入联合维生素D_(2)注射液治疗婴幼儿喘息的临床疗效  

Clinical efficacy of nebulized inhalation of budesonide suspension combined with vitamin D_(2) injection in the treatment of infant wheezing

作　　者：张娜[1] 黄应希[1] 陈小丽 邓添[1] 刘祎[1] 熊敏 ZHANG Na;HUANG Yingxi;CHEN Xiaoli;DENG Tian;LIU Yi;XIONG Min(Department of Pediatrics,the Second Affiliated Hospital of Yichun University,Yichun,Jiangxi,336000,China)

机构地区：[1]宜春学院第二附属医院儿科,江西宜春336000

出　　处：《当代医学》2022年第26期30-34,共5页Contemporary Medicine

摘　　要：目的探讨布地奈德混悬液雾化吸入联合维生素D_(2)注射液治疗婴幼儿喘息的临床疗效。方法选取2018年1月至2020年10月本院收治的80例婴幼儿喘息患儿作为研究对象,采用奇偶数法分为观察组与对照组,各40例。对照组给予维生素D_(2)注射液治疗,观察组在对照组基础上给予布地奈德混悬液雾化吸入治疗,比较两组临床症状(喘息、咳嗽、喘鸣音)消失时间和治疗前后血清25-羟维生素D_(3)[25-(OH)D_(3)]、免疫球蛋白A(IgA)水平、肺功能指标[呼气时间(Te)、潮气量(VT)、吸气时间(Ti)]及不良反应发生情况。结果观察组喘息消失时间[(4.78±2.03)d]、咳嗽消失时间[(3.65±1.59)d]、喘鸣音消失时间[(3.56±1.74)d]均短于对照组[(7.12±3.35)、(5.89±2.13)、(6.28±1.88)d],差异有统计学意义(P<0.05)。治疗7 d后,两组25-(OH)D_(3)、IgA水平均高于治疗前,且观察组[(46.25±6.47)mmol/L、(0.59±0.13)g/L]均高于对照组[(34.25±5.46)mmol/L、(0.37±0.18)g/L],差异有统计学意义(P<0.05)。治疗7 d后,两组Te、Ti均长于治疗前,VT均高于治疗前,且观察组Te、Ti[(0.63±0.05)、(0.68±0.08)s]均长于对照组[(0.50±0.06)、(0.62±0.10)s],VT[(8.06±1.05)ml/kg]高于对照组[(7.16±0.85)ml/kg],差异有统计学意义(P<0.05)。观察组不良反应发生率(7.50%)略低于对照组(12.50%),但差异无统计学意义。结论布地奈德混悬液雾化吸入联合维生素D_(2)注射液治疗婴幼儿喘息效果显著,可快速缓解患儿临床症状,改善血清25-(OH)D_(3)、IgA水平,促进肺功能恢复,减少不良反应的发生,值得临床推广应用。Objective To explore the clinical efficacy of nebulized inhalation of budesonide suspension combined with vitamin D_(2)injection in the treatment of infant wheezing.Methods 80 infants with wheezing admitted to our hospital from January 2018 to October 2020 were selected as the research subjects,and they were divided into the observation group and the control group according to odd-even method,with 40 cases in each group.The control group was treated with vitamin D_(2)injection,while the observation group was treated with nebulized inhalation of budesonide suspension on the basis of the control group.The disappearance time of clinical symptoms(wheezing,cough,stridor),and the levels of serum 25-hydroxyvitamin D_(3)[25-(OH)D_(3)],immunoglobulinA(IgA),pulmonary function indexes(expiratory time[Te],tidal volume[VT],inspiratory time[Ti])before and after treatment and incidence of adverse reactions were compared between the two groups.Results The disappearance time of wheezing([4.78±2.03]d),cough([3.65±1.59]d)and stridor([3.56±1.74]d)in the observation group were shorter than those in the control group([7.12±3.35],[5.89±2.13],[6.28±1.88]d),and the difference was statistically significant(P<0.05).After 7 d of treatment,the levels of 25-(OH)D_(3) and IgA in the two groups were higher than those before treatment,and the observation group([46.25±6.47]mmol/L,[0.59±0.13]g/L)were higher than those in the control group([34.25±5.46]mmol/L、[0.37±0.18]g/L),and the difference was statistically significant(P<0.05).After 7 d of treatment,the Te and Ti in the two groups were longer than those before treatment,and the VT were higher than that before treatment,and the Te and Ti([0.63±0.05]and[0.68±0.08]s)in the observation group were longer than those in the control group([0.50±0.06],[0.62±0.10]s),and the VT([8.06±1.05]ml/kg)was higher than that in the control group([7.16±0.85]ml/kg),and the difference was statistically significant(P<0.05).The incidence of adverse reactions in the observation group(7.50%)was lower than

关 键 词：婴幼儿 喘息 布地奈德混悬液 维生素D_(2)注射液 25-羟维生素D_(3) 免疫球蛋白A 肺功能 

分 类 号：R725.6[医药卫生—儿科]