喜炎平注射液治疗急性加重期慢性阻塞性肺疾病的疗效及对患者白细胞介素-8与肿瘤坏死因子-α水平的影响  

Efficacy of Xiyanping injection in the treatment of acute exacerbation of chronic obstructive pulmonary disease and its effect on the levels of interleukin-8 and serum tumor necrosis factor-αin patients

作　　者：赵洁敏 余淑芳 左万里 ZHAO Jiemin;YU Shufang;ZUOWanli(Department of Respiratory Medicine,Jiangmen Central Hospital/Jiangmen Hospital Affiliated to Sun Yat-sen University,Jiangmen,Guangdong,529030,China)

机构地区：[1]江门市中心医院/中山大学附属江门医院呼吸科,广东江门529030

出　　处：《当代医学》2022年第26期37-40,共4页Contemporary Medicine

摘　　要：目的探讨喜炎平注射液治疗急性加重期慢性阻塞性肺疾病(COPD)的疗效及对患者白细胞介素-8(IL-8)与肿瘤坏死因子-α(TNF-α)水平的影响。方法选取2019年5月至2020年5月本院收治的100例急性加重期COPD患者作为研究对象,随机分为对照组(布地奈德治疗)与观察组(布地奈德+喜炎平注射液治疗),每组50例。比较两组临床疗效及治疗前后肺功能指标、血清炎症因子水平、血气指标。结果观察组治疗总有效率为90.00%,高于对照组的76.00%,差异有统计学意义(P<0.05)。治疗前,两组呼气峰流速(PEF)、最大呼气中期流速(MMEF)、用力肺活量(FVC)水平比较差异无统计学意义;治疗后,两组PEF、MMEF、FVC水平均高于治疗前,且观察组高于对照组(P<0.05)。治疗前,两组IL-8和TNF-α水平比较差异无统计学意义;治疗后,两组IL-8和TNF-α水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05)。治疗前,两组PaCO_(2)、PaO_(2)水平比较差异无统计学意义;治疗后,两组PaCO_(2)均低于治疗前,PaO2均高于治疗前,且观察组PaCO_(2)低于对照组,PaO2高于对照组,差异有统计学意义(P<0.05)。结论喜炎平注射液治疗急性加重期COPD疗效显著,可改善患者肺功能及机体内炎症因子水平,利于改善患者预后,值得临床推广应用。Objective To investigate the curative effect of Xiyanping injection in the treatment of acute exacerbation of chronic obstructive puldoi:monary disease(COPD)and its effect on the levels of interleukin-8(IL-8)and serum tumor necrosis factor-α(TNF-α)in patients.Methods 100 patients with acute exacerbation of COPD who were treated in our hospital from May 2019 to May 2020 were selected as the research subjects,and they were randomly divided into the control group(budesonide treatment)and the observation group(budesonide+Xiyanping injection treatment),with 50 cases in each group.The clinical efficacy and the pulmonary function indexes,serum inflammatory factors levels and blood gas indexes were compared between the two groups before and after treatment.Results The total effective rate of the observation group was 90.00%,which was higher than 76.00%in the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in the levels of peak expiratory flow(PEF),maximal mid-expiratory flow curve(MMEF),and forced vital capacity(FVC)between the two groups;after treatment,the levels of PEF,MMEF,and FVC in the two groups were higher than those before treatment,and the observation group was higher than the control group(P<0.05).Before treatment,there was no significant difference in the levels of IL-8 and TNF-αbetween the two groups;after treatment,the levels of IL-8 and TNF-αin the two groups were lower than those before treatment,and the observation group was lower than the control group,and the difference was statistically significant(P<0.05).Before treatment,there was no significant difference in partial pressure of carbon dioxide(PaCO_(2))and partial pressure of oxygen(PaO_(2))between the two groups;after treatment,PaCO_(2) in the two groups were lower than before treatment,and PaO_(2) was higher than before treatment,and PaCO_(2) in the observation group was lower than that in the control group,and PaO_(2) was higher than that in the control group,the diff

关 键 词：慢性阻塞性肺疾病 喜炎平注射液 布地奈德 肺功能 

分 类 号：R563.9[医药卫生—呼吸系统]