甘精胰岛素与阿卡波糖片联合格列美脲治疗继发性磺脲类药物失效2型糖尿病的临床疗效  

Clinical efficacy of insulin glargine and acarbose tablets combined with glimepiride in the treatment of type 2 diabetes mellitus with secondary failures of sulfonylurea

作　　者：梁潇予 LIANG Xiaoyu(Department of Pharmacy,Shenyang Fifth People's Hospital,Shenyang,Liaoning,110020,China)

机构地区：[1]沈阳第五人民医院药剂科,辽宁沈阳110020

出　　处：《当代医学》2022年第26期65-68,共4页Contemporary Medicine

摘　　要：目的甘精胰岛素与阿卡波糖片联合格列美脲治疗继发性磺脲类药物失效2型糖尿病(DM)的临床疗效。方法选取2019年1月至2020年1月本院收治的80例继发性磺脲类药物失效的2型DM患者作为研究对象,采用随机数字表法分为两组,每组40例。甲组给予阿卡波糖片联合甘精胰岛素治疗,乙组在甲组基础上联合格列美脲治疗,比较两组治疗前后血糖指标、胰岛素功能指标及临床疗效。结果治疗后,两组糖化血红蛋白(HbA1c)、餐后2 h血糖(2 h PG)及空腹血糖(FBG)水平均低于治疗前,且乙组低于甲组,差异有统计学意义(P<0.05)。治疗后,两组稳态模型评估的胰岛素抵抗指数(HOMA-IR)均低于治疗前,空腹胰岛素(FINS)水平高于治疗前,且乙组HOMA-IR水平低于甲组,FINS水平高于甲组,差异有统计学意义(P<0.05);两组治疗前后组内及组间胰岛β细胞功能(HOMA-β)水平比较差异无统计学意义。乙组治疗总有效率为97.50%,高于甲组的82.50%,差异有统计学意义(P<0.05)。结论阿卡波糖与甘精胰岛素联合格列美脲治疗磺脲类药物治疗失效的2型DM效果显著,可有效改善患者血糖指标及胰岛素功能,值得临床推广应用。Objective To investigate the clinical efficacy of insulin glargine and acarbose tablets combined with glimepiride in the treatment of type 2 diabetes mellitus(DM)patients with secondary failures of sulfonylurea.Methods A total of 80 patients with type 2 DM with secondary failures of sulfonylurea who were admitted to our hospital from January 2019 to January 2020 were selected as the research subjects,and they were divided into two groups according to random number table method,with 40 cases in each group.Group A was treated with acarbose tablets combined with insulin glargine,and group B was treated with glimepiride on the basis of group A,the levels of blood glucose indexes,insulin function indexes before and after treatment and clinical efficacy were compared between the two groups.Results After treatment,the levels of glycosylated hemoglobin(HbA1c),2-hour post-meal blood glucose(2 h PG)and fasting blood glucose(FBG)in the two groups were lower than those before treatment,and group B was lower than group A,and the difference was statistically significant(P<0.05).After treatment,the homeostasis model assessment of insulin resistance index(HOMA-IR)in the two groups were lower than those before treatment,and the levels of fasting insulin(FINS)were higher than those before treatment,and the level of HOMA-IR in group B was lower than that group A,and the level of FINS was higher than that of group A,and the difference was statistically significant(P<0.05);there was no significant difference in the homeostasis model assessment ofβ-cell function(HOMA-β)between the two groups before and after treatment.The total effective rate in group B was 97.50%,which was higher than 97.50%in group A,and the difference was statistically significant(P<0.05).Conclusion Acarbose and insulin glargine combined with glimepiride have significant effect in the treatment of type 2 DM with secondary failures of sulfonylurea,and can effectively improve the blood glucose index and insulin function of patients,which is worthy of clinical appli

关 键 词：磺脲类药物 阿卡波糖 格列美脲 甘精胰岛素 2型糖尿病 

分 类 号：R587.1[医药卫生—内分泌]