噻托溴胺联合糖皮质激素治疗哮喘-慢阻肺重叠综合征患者的效果及对肺功能、CAT评分的影响  

Effect of tiotropium bromide combined with glucocorticoid in the treatment of patients with asthma-chronic obstructive pulmonary overlap syndrome and its influences on lung function and CAT score

作　　者：张光只 李均[1] ZHANG Guangzhi;LI Jun(Comprehensive Outpatient Department,Luoyang Institute of Electro-Optical Equipment,Aviation Industry Corporation of China,LTD.Luoyang 471000,China)

机构地区：[1]中国航空工业集团公司洛阳电光设备研究所综合门诊部,河南洛阳471000

出　　处：《临床医学研究与实践》2023年第19期72-75,共4页Clinical Research and Practice

摘　　要：目的探讨噻托溴胺联合糖皮质激素治疗哮喘-慢阻肺重叠综合征患者的效果。方法选取2020年5月至2021年5月本院门诊收治的160例哮喘-慢阻肺重叠综合征患者,依据就诊时间顺序的奇偶性将其分为对照组(80例,糖皮质激素治疗)和观察组(80例,在对照组基础上联合噻托溴铵治疗)。比较两组的治疗效果。结果治疗后3个月,观察组的用力肺活量(FVC)、第1秒用力呼吸容积(FEV_(1))、FEV_(1)/FVC、呼气峰流速(PEF)、最大通气量(MVV)高于对照组,差异具有统计学意义(P<0.05)。治疗后14 d,观察组的C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平低于对照组,白细胞介素-10(IL-10)水平高于对照组,差异具有统计学意义(P<0.05)。治疗后3个月,观察组的膈肌厚度、膈肌活动度、氧合指数高于对照组,动脉血二氧化碳分压(PaCO_(2))、慢性阻塞性肺疾病评估测试(CAT)评分低于对照组,差异具有统计学意义(P<0.05)。结论噻托溴铵联合糖皮质激素可有效缓解哮喘-慢阻肺重叠综合征患者的炎症反应,改善呼吸指标,促进肺功能恢复。Objective To investigate the effect of tiotropium bromide combined with glucocorticoid in the treatment of patients with asthma-chronic obstructive pulmonary overlap syndrome.Methods A total of 160 patients with asthma-chronic obstructive pulmonary overlap syndrome admitted in our hospital from May 2020 to May 2021 were selected and divided into control group(80 cases,glucocorticoid treatment)and observation group(80 cases,combined with tiotropium bromide treatment on the basis of control group)according to the parity of treatment time sequence.The therapeutic effects of the two groups were compared.Results Three months after treatment,the forced vital capacity(FVC),forced expiratory volume in one second(FEV_(1)),FEV_(1)/FVC,peak expiratory flow(PEF)and maximal voluntary ventilation(MVV)in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).At 14 d after treatment,the levels of C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in the observation group were lower than those in the control group,and the level of interleukin-10(IL-10)was higher than that in the control group,the differences were statistically significant(P<0.05).Three months after treatment,the diaphragm thickness,diaphragm activity and oxygenation index of the observation group were higher than those of the control group,the arterial partial pressure of carbon dioxide(PaCO_(2))and Chronic Obstructive Pulmonary Disease Assessment Test(CAT)score were lower than those of the control group,the differences were statistically significant(P<0.05).Conclusion Tiotropium bromide combined with glucocorticoid can effectively alleviate the inflammatory reaction of patients with asthma-chronic obstructive pulmonary overlap syndrome,improve respiratory indexes and promote the recovery of lung function.

关 键 词：糖皮质激素 噻托溴铵 哮喘-慢阻肺重叠综合征 肺功能 

分 类 号：R562.25[医药卫生—呼吸系统]