乙肝患者血清流行病学调查与HBV DNA载量的相关性  

Correlation between Serum Epidemiological Investigation of Hepatitis B Patients and HBV DNA Load

作　　者：吴宇清 WU Yuqing(Department of Infection,Lishui District People’s Hospital,Nanjing City,Jiangsu Province 211200)

机构地区：[1]江苏省南京市溧水区人民医院感染科,211200

出　　处：《医学理论与实践》2023年第13期2178-2181,共4页The Journal of Medical Theory and Practice

摘　　要：目的:探讨乙肝患者血清流行病学调查与乙型肝炎病毒核酸(HBV DNA)载量的相关性。方法:抽取2017年2月—2022年2月我院感染科收治患者135例,采用分层抽取的方式从整群中抽样,对乙肝感染相关因素的单因素以及多因素进行分析,同时检测乙肝血清免疫标志物(HBV M)结果与HBV DNA载量,分析HBV M与HBV DNA的相关性。结果:HBsAg阳性率高低与家族史、传染源知晓情况、传播途径知晓情况、是否为城镇居民、是否有美容美发外伤史、是否有输血史、是否接种乙肝疫苗免疫有关(P<0.05)。以HBsAg是否阳性为因变量,单因素分析存在统计学意义的自变量,采用Logistic回归分析,家族史、是否有美容美发外伤史、是否有输血史与乙肝感染呈现正相关(OR值=3.62、3.81、4.40);传播途径知晓情况、是否为城镇居民、传染源知晓情况、是否接种乙肝疫苗免疫呈负相关(OR值=0.24、0.22、0.18、0.08)。Cut-off值选定为200IU/ml,观察对比大三阳与小三阳患者HBV M结果与HBV DNA载量,Ⅰ组HBV DNA阳性率为75.00%,Ⅱ组HBV DNA阳性率为71.43%,组间对比差异无统计学意义(P>0.05);Ⅰ组、Ⅱ组、Ⅲ组、Ⅳ组组间对比,数据差异具有统计学意义(P=0.000)。对HBeAg和HBV DNA载量进行相关性分析,结果显示HBeAg和HBV DNA载量存在正相关(r=0.894,P<0.01)。HBeAg表达水平随着HBV DNA载量增高而增高。将135例患者分为HBeAg阴性、HBeAg阳性,两组结果对比,HBeAg阴性患者HBV DNA载量多处于低水平。结论:乙肝病毒感染可能与家族史、传染源知晓情况、传播途径知晓情况、是否为城镇居民、是否有输血史、是否接种乙肝疫苗免疫有关,HBV M结果与HBV DNA存在显著相关性,通过检测HBV DNA载量,可以用于评估乙肝患者的病情以及疗效。Objective:To explore the correlation between serum epidemiological survey of hepatitis B patients and HBV DNA load.Methods:135 inpatients in our department from February 2017 to February 2022 were sampled from the whole cluster by stratified sampling,and the univariate and multifactorial factors related to hepatitis B infection were analyzed.At the same time,HBV M and HBV DNA load were detected,and the correlation between HBV M and HBV DNA was analyzed.Results:The positive rate of HBsAg was related to family history,knowledge of the source of infection,knowledge of the route of transmission,whether it was a city resident,history of hairdressing,history of blood transfusion,and vaccination against hepatitis B vaccine(P<0.05).Taking whether HBsAg is positive or not as the dependent variable,there are statistically significant independent variables in univariate analysis.By Logistic regression analysis,family history,history of beauty salon and blood transfusion are positively correlated with hepatitis B infection(OR value=3.62,3.81,4.40).There is a negative correlation between the knowledge of the route of transmission,whether people are urban residents,the knowledge of the source of infection and whether they are vaccinated with hepatitis B vaccine(OR value=0.24,0.22,0.18,0.08).The Cut-off value was selected as 200IU/ml,and the results of HBV M and HBV DNA load of patients with HBsAg,HBeAg,Anti-HBc positive and HBsAg,Anti-HBe,Anti-HBc positive were observed and compared.The positive rate of HBV DNA in groupⅠwas 75.00%,and that in groupⅡwas 71.43%,but there was no statistical significance between the two groups(P>0.05).Compared with groupⅠ,groupⅡ,groupⅢand groupⅣ,the data difference was statistically significant(P=0.000).The correlation analysis between HBeAg and HBV DNA load showed that there was a positive correlation between HBeAg and HBV DNA load(r=0.894,P<0.01).The expression water of HBeAg increased with the increase of HBV DNA load.135 patients were divided into HBeAg-negative and HBeAg-positive.

关 键 词：乙肝 血清流行病学 HBV DNA载量 相关性 

分 类 号：R512.6[医药卫生—内科学]