高尿酸血症合并肾结石中医体质特点和基于LASSO回归的危险因素分析  

Traditional Chinese Medicine Constitution Characteristics of Hyperuricemia Complicated with Renal Calculi and Risk Factors Analysis Based on LASSO Regression

作　　者：曹凤娇[1] 白雪娇 侯秀娟[1] CAO Fengjiao;BAI Xuejiao;HOU Xiujuan(Dongfang Hospital in Beijing University of Chinese Medicine,Beijing 100078,China)

机构地区：[1]北京中医药大学东方医院,北京100078

出　　处：《中医药导报》2023年第6期106-110,共5页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：北京市丰台区临床重点专科(风湿科)项目(040104001009)。

摘　　要：目的:探讨高尿酸血症(HUA)合并肾结石患者的中医体质分布特点,并基于LASSO回归对HUA合并肾结石进行危险因素分析。方法:分析1266例HUA患者的体检资料,根据肾结石诊断分为HUA合并肾结石组(276例)和HUA未合并肾结石组(990例)。收集体检者年龄、性别、体质量指数、血糖、血脂等资料,采用SPSS 26.0进行统计学分析。结果:HUA合并肾结石患者的体质分布由高至低依次为痰湿质>湿热质>气虚质>阴虚质>阳虚质>平和质>气郁质、血瘀质>特禀质;不同性别的HUA合并肾结石患者体质分布有差异,男性群体中痰湿质、湿热质高于女性群体(P<0.05);50以上患病人群中,血瘀质最常见;LASSO回归显示年龄、舒张压、总胆固醇、甘油三酯是HUA合并肾结石的危险因素(P<0.05),ROC曲线下面积AUC为0.677[95%CI(0.641,0.713)],灵敏度为0.605,特异度为0.684,阈值为0.210,Hosmer-Lemeshorw拟合优度检验P=0.370。结论:湿热质、痰湿质是HUA合并肾结石人群的高发体质类型,年龄、舒张压、总胆固醇、甘油三酯是HUA人群发生肾结石的相关危险因素。Objective:To investigate the characteristics of traditional Chinese medicine(TCM)constitution and the risk factors based on LASSO regression.Method:The physical examination data of 1266 patients with HUA was reviewed.The patients were divided into renal calculi group(276 cases)and no renal calculi group(990 cases)according to the presence or absence of renal calculi.Physical examination data such as age,gender,body mass index,blood glucose and lipid were collected from the examinees,and the data were statistically analyzed by SPSS 26.0 software.Results:The distribution of constitution in patients with HUA combined with renal calculi from high to low is as follows:phlegm dampness quality>damp heat quality>qi deficiency quality>yin deficiency quality>yang deficiency quality>peace quality>qi depression quality and blood stasis quality>special quality.The physical distribution of patients with HUA combined with renal calculi differed between genders,with a high proportion of phlegm dampness and damp heat qualities in the male group(P<0.05).Blood stasis quality is the most common quality among people with over 50.LASSO regression showed that age,diastolic pressure,total cholesterol and triglyceride were risk factors for HUA complicated with renal calculi(P<0.05),and AUC under ROC curve was 0.677[95%CI(0.641,0.713)],with sensitivity=0.605,specificity=0.684,threshold=0.210,and H-L goodness of fit test P=0.370.Conclusion:Damp heat and phlegm dampness qualities are the most prevalent TCM constitution in people with HUA combined with renal calculi,and age,diastolic pressure,total cholesterol and triglyceride are risk factors associated with the development of renal calculi in people with HUA.

关 键 词：高尿酸血症 肾结石 湿热质 痰湿质 中医体质 LASS0回归 危险因素 

分 类 号：R211[医药卫生—中医学]