联合药物与单纯药物治疗中重度类风湿性关节炎的临床疗效比较  

Comparison of Clinical Efficacy between Combined Drugs and Simple Drugs in the Treatment of Moderate to Severe Rheumatoid Arthritis

作　　者：张瑾 ZHANG Jin(Nanjing Jiangning Hospital,Nanjing 211100,China)

机构地区：[1]南京市江宁医院,江苏南京211100

出　　处：《中国医药指南》2023年第18期79-81,共3页Guide of China Medicine

摘　　要：目的比较联合药物与单纯药物治疗中重度类风湿性关节炎的临床疗效。方法选取南京市江宁医院收治的93例中重度风湿性关节炎患者,按照电脑盲选方式分为对照组、观察A组、观察B组,分别采取单纯氨甲蝶呤治疗、氨甲蝶呤联合柳氨磺胺吡啶治疗、氨甲蝶呤联合来氟米特治疗。结果治疗后,观察A组、观察B组的总有效率均比对照组高(P<0.05);观察A组、观察B组的晨僵时间都比对照组短,关节肿胀数均比对照组少(P<0.05);观察A组、观察B组血沉、C-反应蛋白、白细胞介素-1、白细胞介素-6均比对照组低(P<0.05);观察A组和观察B组VAS评分低于对照组(P<0.05);观察A组和观察B组患者治疗满意度都比对照组高(P<0.05);观察A组和观察B组的SF-36评分都比对照组高(P<0.05)。上述指标在观察A组与观察B组间差异均无显著性(P>0.05)。结论中重度类风湿性关节炎的联合药物较单纯药物治疗效果较显着,能够改善患者临床症状,减轻疼痛,同时还能提高生活水平及患者治疗满意度。Objective The clinical efficacy of combined drugs and simple drugs in the treatment of moderate to severe rheumatoid arthritis was compared.Methods A total of 93 patients with moderate to severe rheumatoid arthritis admitted to Nanjing Jiangning Hospital were selected and divided into control group,observation group A and observation group B according to computer blind selection.They were treated with methotrexate alone,methotrexate combined with sulfasalazine,and methotrexate combined with leflunomide.Results After treatment,the total effective rate of observation group A and observation group B was higher than that of control group(P<0.05).The morning stiffness time of the observation group A and the observation group B was shorter than that of the control group,and the number of joint swelling was less than that of the control group(P<0.05).The erythrocyte sedimentation rate,C-reactive protein,interleukin-1 and interleukin-6 in the observation group A and the observation group B were lower than those in the control group(P<0.05).The VAS scores of observation group A and observation group B were lower than those of control group(P<0.05).The treatment satisfaction of patients in observation group A and observation group B was higher than that in control group(P<0.05).The SF-36 data of observation group A and observation group B were higher than those of control group(P<0.05).There was no significant difference in the above indexes between the observation group A and the observation group B(P>0.05).Conclusion The combined medication treatment for moderate to severe rheumatoid arthritis has a significant effect,which can improve clinical symptoms,alleviate pain and suffering,and also improve living standards to meet patient satisfaction standards.It is worthy of clinical attention and strong adoption.

关 键 词：类风湿性关节炎 氨甲蝶呤 疗效 柳氨磺胺吡啶 

分 类 号：R593.22[医药卫生—内科学]