中药组分抗糖尿病心肌病作用机制研究进展  

Research Progress on Anti-diabetic Cardiomyopathy Mechanism of Traditional Chinese Medicine Components

作　　者：李春锋 姚鹏宇 赵鑫[4] 徐彦[5] 高琛琛 LI Chunfeng;YAO Pengyu;ZHAO Xin;XU Yan;GAO Chenchen(Zibo Central Hospital,Zibo Shandong China 255000;Shandong Engineering Technology Laboratory,Suzhou Institute of Biomedical Engineering Technology,China Academy of Sciences,Jinan Shandong China 250102;Jinan Guoke Medical Science and Technology Development Co.,Ltd.,Jinan Shandong China 250102;The Affiliated Hospital to Shandong University of Traditional Chinese Medicine,Jinan Shandong China 250014;Zibo Traditional Chinese Medicine Hospital,Zibo Shandong China 255300)

机构地区：[1]淄博市中心医院,山东淄博255000 [2]中国科学院苏州生物医学工程技术研究所山东工程技术研究室,山东济南250102 [3]济南国科医工科技发展有限公司,山东济南250102 [4]山东中医药大学附属医院,山东济南250014 [5]淄博市中医院,山东淄博255300

出　　处：《中医学报》2023年第8期1675-1685,共11页Acta Chinese Medicine

基　　金：2022年山东省中医药新产品研发推广项目(2022-3)。

摘　　要：中药组分在糖尿病心肌病(diabetic cardiomyopathy,DCM)的治疗中具有多途径、多功效、全过程干预的优势。黄酮类、萜类、多酚类、生物碱类等中药组分抗DCM的作用较为显著,其中黄酮类化合物的文献报道最多,11种抗糖尿病心肌病的中药黄酮类组分构效关系明确,均呈现典型黄酮结构,具有抗炎、抗氧化、抗凋亡和抗纤维化等共性作用。中药组分抗DCM具有“多机制共存、共性机制显著”特征,NF-κB、Nrf2是最常出现的相关信号通路。但目前DCM的中药组分研究多停留在体外细胞实验及动物实验阶段,可进一步从分子水平深入探讨,对研究较成熟的中药组分开展一定的临床试验。同时需进一步明确中药组分抗DCM的作用靶点、分子信号通路及复杂的调控网络,明确药物不良反应,并引入纳米材料学等现代科技赋能中药组分研究。Traditional Chinese medicine components have the advantages of multi-channel,multi-efficacy and whole-process intervention in the treatment of diabetic cardiomyopathy(DCM).Flavonoids,terpenoids,polyphenols,alkaloids and other components of traditional Chinese medicine have obvious anti-DCM effects,among which flavonoids are the most reported in the literature,and the structure-activity relationship of flavonoids in 11 traditional Chinese medicines against diabetic cardiomyopathy is clear,all of which show typical flavonoid structures,and have the common effects of anti-inflammatory,antioxidant,anti-apoptosis and anti-fibrosis.Anti-DCM of traditional Chinese medicine components has the characteristics of"multi-mechanism coexistence and obvious common mechanism",and NF-κB and Nrf2 are the most common related signal pathways.However,at present,the research on TCM components of DCM mostly stays in the stage of in vitro cell experiment and animal experiment,which can be further discussed at the molecular level and some clinical trials can be carried out for the more mature TCM components.At the same time,it is necessary to further improve the target,molecular signal pathway and complex regulatory network,clarify the adverse drug reactions,and introduce modern science and technology such as nano-materials science to empower the research of traditional Chinese medicine components.

关 键 词：糖尿病心肌病 中药组分 作用机制 研究进展 

分 类 号：R285[医药卫生—中药学]