补脾益肾方联合艾灸对溃疡性结肠炎的改善作用及机制研究  

Improving Effect and Mechanism of Bupi Yishen Recipe Combined with Moxibustion on Ulcerative Colitis

作　　者：张慧俭[1] 刘世举[2] ZHANG Huijian;LIU Shiju(Henan University of Chinese Medicine,Zhengzhou Henan China 450046;The Third Affiliated Hospital to Henan University of Chinese Medicine,Zhengzhou Henan China 450008)

机构地区：[1]河南中医药大学,河南郑州450046 [2]河南中医药大学第三附属医院,河南郑州450008

出　　处：《中医学报》2023年第8期1771-1777,共7页Acta Chinese Medicine

基　　金：河南省科技厅资助项目(202102310500);河南省教育厅高等学校重点科研项目(20A360015);河南省中医药拔尖人才培养项目专项课题项目(2022ZYBJ20)。

摘　　要：目的:探讨补脾益肾方联合艾灸对溃疡性结肠炎的改善作用及机制。方法:76例溃疡性结肠炎患者,按随机数字表法分为两组。对照组38例,采用美沙拉嗪+艾灸治疗;观察组38例,在对照组基础上给予补脾益肾方治疗。两组患者连续治疗4周后,对治疗效果、中医证候积分、肠道菌群、免疫功能及血清炎症因子表达水平进行评价。结果:观察组治疗有效率97.37%优于对照组的78.95%(P<0.05);治疗后久泻不止、滑脱不禁、形寒肢冷、腰膝酸软评分低于对照组,差异有统计学意义(P<0.05)。观察组治疗后双歧杆菌、乳酸杆菌高于对照组,肠杆菌、肠球菌低于对照组,血清白细胞介素-6(interleukin-6,IL-6)、IL-8、高迁移率组蛋白B1(high mobility group protein B1,HMGB1)表达低于对照组,辅助性T细胞17(helper T cells 17,Th17)、Th17/调节性T细胞(regulatory T cells,Treg)低于对照组,Treg高于对照组,差异有统计学意义(P<0.05)。两组患者在治疗期间未出现与治疗有关的不良反应,均顺利完成治疗。结论:补脾益肾方联合艾灸可调节溃疡性结肠炎患者肠道菌群结构,提高临床治疗效果,抑制炎症反应,调节机体免疫功能。Objective:To investigate the effect and mechanism of Bushi Yishen Recipe combined with moxibustion on ulcerative colitis.Methods:76 patients with ulcerative colitis were divided into two groups according to random number table method.Control group 38 cases were treated with mesalazine plus moxibustion;Observation group 38 cases,on the basis of the basis of Busi Yishen Recipe treatment;After 4 weeks of continuous treatment,the therapeutic effect,TCM syndrome score,intestinal flora,immune function and serum inflammatory factor expression were evaluated and compared between the two groups.Results:The effective rate of the observation group was 97.37%compared with 78.95%in the control group(P<0.05).After treatment,the scores of chronic diarrhea,slippage,cold shape and cold limbs,waist and knee tenderness were lower than those of control group,and the differences were statistically significant(P<0.05).After treatment,bifidobacteria,lactobacilli is higher than the control group,enterobacter and enterococcus in observation group is lower than the that of the control group,serum interleukin 6(IL-6),IL-8 and high mobility group protein B1(HMGB1)expression is lower than the control group,helper T cells17(Th17)and Th17/Treg were lower than those in control group,and regulatory T cells(Treg)were higher than those in control group,the difference was statistically significant(P<0.05).There were no treatment-related adverse reactions during 4 weeks of treatment in both groups,and the treatment was successfully completed.Conclusion:Bupi Yishen Recipe combined with moxibustion can regulate the intestinal flora structure of ulcerative colitis patients,improve the clinical therapeutic effect,inhibit the inflammatory response and regulate the immune function.

关 键 词：溃疡性结肠炎 补脾益肾方 艾灸 肠道菌群 免疫功能 炎症因子 

分 类 号：R245.746.1[医药卫生—针灸推拿学]