STEMI患者介入术前后GDF-15、Gal-3、TN-C水平对比研究  

Comparative study of GDF-15,Gal-3 and TN-C levels in STEMI patients before and after intervention

作　　者：卢冬雪 李大鹏[1] 李婷婷[1] 张立敏[1] 李志[1] LU Dongxue;LI Dapeng;LI Tingting;ZHANG Limin;LI Zhi(Department of Cardiology of the Central Hospital of Jiamusi City,Jiamusi 154002 Heilongjiang,China)

机构地区：[1]佳木斯市中心医院心血管内科,黑龙江佳木斯154002

出　　处：《中国民康医学》2023年第12期32-34,共3页Medical Journal of Chinese People’s Health

基　　金：黑龙江省卫生健康委科研课题(20210303010387)。

摘　　要：目的:比较急性ST段抬高型心肌梗死(STEMI)患者经皮冠状动脉介入术(PCI)前后血清生长分化因子-15(GDF-15)、半乳糖凝集素-3(Gal-3)、肌腱蛋白-C(TN-C)水平。方法:回顾性分析2022年1—12月该院收治的100例STEMI患者的临床资料,纳入观察组。PCI术后随访3个月,根据STEMI患者心血管不良事件发生率,分为预后良好组与预后不良组,另选取该院同期健康体检者70名为对照组。比较各组血清GDF-15、Gal-3、TN-C水平,并采用点二列相关性分析血清GDF-15、Gal-3、TN-C水平与PCI术后STEMI患者不良预后的相关性。结果:观察组GDF-15、Gal-3、TN-C水平均高于对照组,差异有统计学意义(P<0.05);预后不良组血清GDF-15、Gal-3、TN-C水平均高于预后良好组,差异有统计学意义(P<0.05);点二列相关性分析结果显示,血清GDF-15、Gal-3、TN-C水平与PCI术后STEMI患者预后不良均呈正相关(r=0.843、0.827、0.835,P均<0.05)。结论:血清GDF-15、Gal-3、TN-C水平与PCI术后STEMI患者预后不良均呈正相关。Objective:To compare the serum levels of growth differentiation factor-15(GDF-15),galectin-3(Gal-3),tenascin-C(TNC)levels in patients with acute ST-segment elevation myocardial infarction(STEMI)before and after percutaneous coronary intervention(PCI).Methods:The clinical data of 100 patients with STEMI admitted to this hospital from January to December 2022 were retrospectively analyzed and included in observation group.These patients were followed up for 3 months after PCI.According to the incidence of cardiovascular adverse events in the STEMI patients,they were divided into good prognosis group and poor prognosis group.In addition,70 healthy subjects in the same period were selected as control group.The levels of serum GDF-15,Gal-3 and TN-C in each group were compared.Point biserial correlation analysis was used to analyze the correlations among the serum GDF-15,Gal-3,and TN-C levels and poor prognosis of the STEMI patients after PCI.Results:The levels of GDF-15,Gal-3 and TN-C in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The levels of serum GDF-15,Gal-3 and TN-C in the poor prognosis group were higher than those in the good prognosis group,and the differences were statistically significant(P<0.05).Point biserial correlation analysis showed that serum GDF-15,Gal-3 and TN-C levels were positively correlated with poor prognosis of the STEMI patients after PCI(r=0.843,0.827,0.835,all P<0.05).Conclusions:The levels of serum GDF-15,Gal-3 and TN-C are positively correlated with the poor prognosis of the STEMI patients after PCI.

关 键 词：经皮冠状动脉介入术 急性ST段抬高型心肌梗死 预后不良 相关性 生长分化因子-15 半乳糖凝集素-3 肌腱蛋白-C 

分 类 号：R542[医药卫生—心血管疾病]