激光散斑衬比血流成像关键技术及应用研究进展  

Advances in Laser Speckle Contrast Imaging:Key Techniques and Applications

作　　者：翟林君 傅玉青 杜永兆 Zhai Linjun;Fu Yuqing;Du Yongzhao(School of Biomedical Science,Huaqiao University,Quanzhou 362021,Fujian,China;College of Engineering,Huaqiao University,Quanzhou 362021,Fujian,China)

机构地区：[1]华侨大学生物医学学院,福建泉州362021 [2]华侨大学工学院,福建泉州362021

出　　处：《中国激光》2023年第9期44-71,共28页Chinese Journal of Lasers

基　　金：福建省自然科学基金面上项目(2021J01321)、泉州市科技计划项目(2019C029R)、集成光电子学国家重点实验室开放课题(IOSKL2020KF25)。

摘　　要：激光散斑衬比血流成像(LSCI)是一种利用激光散斑强度的时空统计特性来实现活体组织血流监测的全场光学成像技术,在临床诊断和生命科学等研究领域具有重要的应用价值。本文在介绍LSCI基本原理的基础上,重点对高信噪比LSCI、高分辨率LSCI、高精度LSCI、大成像深度LSCI和新型LSCI系统等关键技术及其应用的研究进展进行综述。首先,综述了各向异性滤波、特征值分解和变换域滤波的高信噪比LSCI技术,并总结了以运动伪影校正、失焦模糊校正和非均匀光强校正为目标的高分辨率LSCI技术的研究现状;然后,以实现高精度LSCI为目标,从静态散射光校正、定量LSCI技术和新型散斑衬比成像算法等方面阐述了高精度LSCI技术的研究进展;最后,总结大成像深度LSCI技术的发展现状与进展,介绍新型LSCI系统及其应用的最新研究成果,并对LSCI技术未来的发展方向和应用功能拓展进行总结和展望。Significance Blood flow is an important parameter for measuring vital signs,and hemodynamic parameters are functional indicators of the microcirculatory system of the skin,brain,heart,liver,kidneys,and other organs.Therefore,dynamic blood flow monitoring has important application value and significance in clinical and basic life science fields,such as clinical diagnosis,intraoperative guidance,drug research,disease mechanism research,and neuroscience.Laser speckle contrast imaging(LSCI)is a full-field optical imaging technique that uses the spatial and temporal statistical properties of laser scattering intensity to monitor the blood flow of tissues in vivo.It uses simple equipment,is non-invasive,and has a fast imaging speed and high spatial resolution.Additionally,it does not require the injection of a contrast agent and can perform continuous measures for a long time.Consequently,it is widely used to measure microcirculatory blood flow parameters such as the vessel diameter,blood flow velocity,blood perfusion,and blood density in tissues and organs.It also can help doctors locate the lesion precisely with clear and accurate blood flow data,and then analyze the corresponding functional response and pathological mechanisms,which has become one of the most important tools for the clinical diagnosis of fundus diseases,skin diseases,brain diseases,and so on.In addition,it is also an important tool for basic life science research in drugs,cardiovascular and cerebrovascular diseases,and brain cognitive and behavioral sciences.Consequently,in-depth research on novel LSCI techniques with high imaging quality is valuable and significant for improving the quality of medical care and promoting the development of basic research in life science.Progress In the past decades,many researchers have conducted extensive researches on how to improve the quality of LSCI and expand the scope of LSCI applications,and they have had positive progress.For example,a few research groups like Luo Qingming and Li Pengcheng at Huazhong Unive

关 键 词：医用光学 生物医学光学成像 激光散斑成像 血流成像 关键技术 应用进展 

分 类 号：Q631[生物学—生物物理学]