《伤寒论》单元药组之方剂计量学解析  

An Analysis of Prescription Metrology of Unit Drug Group in Treatise on Febrile Diseases

作　　者：王苗[1] 周铭心[2] WANG Miao;ZHOU Mingxin(The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830054,Xinjiang,China;Xinjiang Medical University,Urumqi 830011,Xinjiang,China)

机构地区：[1]新疆医科大学第一附属医院,新疆乌鲁木齐830054 [2]新疆医科大学,新疆乌鲁木齐830011

出　　处：《实用中医内科杂志》2023年第5期4-7,共4页Journal of Practical Traditional Chinese Internal Medicine

基　　金：国家中医药管理局周铭心全国名中医传承工作室建设项目(201808);第七批全国老中医药专家学术经验继承项目([2022]76号);省部共建中亚高发病成因与防治国家重点实验室中医专项(SKL-HIDCA-2021-ZY8);新疆维吾尔自治区自然科学基金项目(2021D01C349)。

摘　　要：目的用方剂计量学方法提取、解析《伤寒论》方剂之药组配伍关系。方法选取《伤寒论》方剂88首,统计用药频数,并进行相关分析、聚类分析,提取其中的药组;引入方剂计量学新立药组分析法,解析药组的配伍特性与运用情况。结果①《伤寒论》88首方剂,全部用药60味,431药次。②对全部用药进行相关和聚类分析,得11个或3药或4药为组合运用单元药组,可视为初选药组。③结合实际方剂加以甄别初选药组,从中确定大枣-生姜-桂枝-甘草、人参-半夏-黄芩-柴胡、石膏-知母-粳米、附子-白术-茯苓、天冬-葳蕤-升麻、桃仁-水蛭-虻虫等10组药为《伤寒论》方剂之常用药组。④解析10个药组,计算其运用频度、亲和度、离组比,以揭示其配对亲和程度及其独立性或依存性关系;分析其成组和离组运用功效,以表明其运用时机。结论《伤寒论》方剂药组为后世医家用药之典范,迄今仍被广泛使用;方剂计量学之药组分析法可以为方剂药组的研究和运用提供科学依据。Objective To extract and analyze the compatibility of prescription groups in Treatise on Febrile Diseasesby means of prescription metrology.Methods Eighty-eight prescriptions in Treatise on Febrile Diseases were selected,the frequency of medication was counted,and correlation analysis and cluster analysis were carried out to extract drug groups.The prescription metrology and new prescription group analysis were introduced to analyze the compatibility and application of the drug group.Results①Eighty-eight prescriptions were used in Treatise on Febrile Diseases,all of which were 60 drugs,totally 431 times.②Correlation and cluster analysis of all drugs showed that 11 or 3 or 4 drugs were used as the combination unit drug groups,which could be regarded as primary drug groups.③The primary drug groups were screened according to the actual prescriptions,from which 10 groups of drugs,including Dazao(Jujubae Fructus)-Shengjiang(Zingiberis Rhizoma Recens)-Guizhi(Cinnamomi Ramulus)-Gancao(Glycyrrhizae Radix Et Rhizoma),Renshen(Ginseng Radix Et Rhizoma)-Banxia(Pinelliae Rhizoma)-Huangqin(Scutellariae Radix)-Chaihu(Bupleuri Radix),Shigao(Gypsum Fibrosum)-Zhimu(Anemarrhenae Rhizoma)-Jingmi(Semen Oryzae Sativae),Fuzi(aconiti lateralis radix praeparata)-Baizhu(Atractylodis Macrocephalae Rhizoma)-Fuling(Poria),Tiandong(Asparagi Radix)-Weirui(Polygonati Odorati Rhizoma)-Shengma(Cimicifugae Rhizoma),Taoren(Persicae Semen)-Shuizhi(Hirudo)-Mangchong(Gadfly),were determined as the regular drug groups of the prescriptions in Treatise on Febrile Diseases.(4)Ten drug groups were analyzed,and their application frequency,affinityand separation ratio were calculated to reveal thepaired affinity and theindependence or dependence relationship.The group and outgroup application efficacy were analyzed to indicate the timing of application.Conclusion The prescription group of Treatise on Febrile Diseases is a model of medicine for later doctors and is still widely used.The drug group analysis method of prescription metrology can provide sc

关 键 词：伤寒论 单元药组 药组分析法 聚类分析 方剂计量学 

分 类 号：R289.1[医药卫生—方剂学]