姜黄素作为潜在的甲基化抑制剂与2型糖尿病关系的研究进展  

Curcumin as a Potential Methylation Inhibitors and the Research Progress of Relationship Between Type 2 Diabetes Mellitus

作　　者：李蕾 段滨红[2] 王丹[2] 向朝峰[2] 刘枝鑫 LI Lei;DUAN Bin-hong;WANG DAN(Jiamusi University,Jiamusi 154000,Jiamusi,China)

机构地区：[1]佳木斯大学,佳木斯154000 [2]黑龙江省医院香坊院区内分泌科,哈尔滨150000 [3]牡丹江医学院,牡丹江157011

出　　处：《航空航天医学杂志》2023年第4期441-444,共4页Journal of Aerospace medicine

基　　金：黑龙江省自然基金联合引导项目LH2021H061资助(姜黄素通过DNMT/TET途径参与糖尿病胰岛素抵抗的研究)。

摘　　要：2型糖尿病(T2DM)是由遗传与环境因素共同作用引起的胰岛素分泌和(或)利用障碍所致的以慢性高血糖为特征的代谢性疾病,发病机制主要是胰岛β细胞功能障碍和胰岛素抵抗,越来越多的研究发现组织相关基因甲基化状态的改变参与T2DM发生发展。姜黄素能够改善胰岛素抵抗及胰岛β细胞功能,并且姜黄素作为甲基化抑制剂,能够通过下调靶基因甲基化水平发挥去甲基化作用。本文对姜黄素和甲基化调控胰岛素抵抗、胰岛β细胞功能相关基因的相关进展进行阐述。Type 2 diabetes mellitus(T2DM)is a metabolic disease characterized by chronic hyperglycemia caused by disturbance of insulin secretion and(or)utilization caused by genetic and environmental factors.The pathogenesis is mainly isletβ-cell dysfunction and insulin resistance.More and more studies have found that changes in methylation status of tissue-related genes are involved in the occurrence and development of T2DM.Curcumin can improve insulin resistance and isletβ-cell function,and curcumin,as a methylation inhibitor,can play a demethylation role by down-regulating the methylation level of target genes.This paper reviews the progress of curcumin and methylation in regulating insulin resistance and isletβ-cell function related genes.

关 键 词：姜黄素 2型糖尿病 甲基化 胰岛素抵抗 胰岛Β细胞功能障碍 

分 类 号：R587.1[医药卫生—内分泌]