宏基因组二代测序诊断肺隐球菌病2例  

Two cases of pulmonary cryptococcosis diagnosed by metagenomic next-generation sequencing

作　　者：于恪 武莉莉[1] 黄河[1] 张敏[1] 邓海燕[1] YU Ke;WU Lili;HUANG He;ZHANG Min;DENG Haiyan(Department of Respiratory and Critical Care Medicine,Shenzhen Second People’s Hospital,the First Affiliated Hospital of Shenzhen University,Shenzhen 518035,China)

机构地区：[1]深圳市第二人民医院(深圳大学第一附属医院)呼吸与危重症医学科,深圳518035

出　　处：《中国真菌学杂志》2023年第3期241-245,共5页Chinese Journal of Mycology

摘　　要：肺隐球菌病是最常见的肺部真菌感染之一,临床及影像学上缺乏特异性,容易误诊及漏诊。肺隐球菌病的诊断多依赖于病原学及组织病理学。近年来兴起的宏基因组二代测序技术,为感染性疾病的早期快速诊治提供了新的思路。本文报道2例既往无免疫抑制性基础疾病,无明显呼吸道症状及阳性体征,仅体检胸部CT发现肺野外带圆形实性结节灶,最终经支气管肺泡灌洗液宏基因组二代测序技术迅速诊断、及时治疗的肺隐球菌病患者的临床特征及诊治经过。Pulmonary cryptococcosis is one of the most common pulmonary fungal infections.It lacks clinical and imaging specificity and is easy to be misdiagnosed and missed.The diagnosis of pulmonary cryptococcosis mostly depends on etiology and histopathology.The metagenomic next-generation sequencing technology that has emerged in recent years provides new ideas for the early and rapid diagnosis and treatment of infectious diseases.This article reports the clinical characteristics and the process of diagnosis and treatment of 2 cases of pulmonary cryptococcosis patients,with no previous immunocompromised diseases and no complaining of respiratory symptoms.Physical examination found no obvious signs,chest computed tomography(CT)scan showed a round solid nodules in the outer area of the lung field.They were finally diagnosed rapidly by the the metagenomic next-generation sequencing(mNGS)technology of bronchoalveolar lavage fluid and received treatment on time.

关 键 词：肺隐球菌病 支气管肺泡灌洗液 宏基因组二代测序 

分 类 号：R519.4[医药卫生—内科学]