鞘内给药对急性期多发性硬化患者的影响  

Impact of intrathecal administration on patients with acute multiple sclerosis

作　　者：毕峰[1] 杨明妍[2] 吴雪姣[3] BI Feng;YANG Mingyan;WU Xuejiao(Department of Neurology,Jilin Neuropsychiatric Hospital,Jilin,Siping 136000,China;Department of Pharmacy,Jilin Neuropsychiatric Hospital,Jilin,Siping 136000,China;Department of Clinical Pharmacy,Jilin Neuropsychiatric Hospital,Jilin,Siping 136000,China)

机构地区：[1]吉林省神经精神病医院神经内科,吉林四平136000 [2]吉林省神经精神病医院药剂科,吉林四平136000 [3]吉林省神经精神病医院临床药学室,吉林四平136000

出　　处：《中国医药科学》2023年第12期137-140,共4页China Medicine And Pharmacy

摘　　要：目的探讨鞘内注射甲泼尼龙对急性期多发性硬化患者神经功能和免疫功能的影响。方法选取2019年1月至2022年1月于吉林省神经精神病医院治疗的多发性硬化患者,选取实施甲泼尼龙静脉滴注治疗的患者30例作为对照组,选取实施甲泼尼龙鞘内注射治疗的患者30例作为观察组,比较两组治疗效果。结果治疗后观察组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前两组的神经功能状况评估量表(EDSS)评分比较,差异无统计学意义(P>0.05),观察组治疗后EDSS评分低于对照组,差异有统计学意义(P<0.05)。观察组生活质量评分高于对照组,差异有统计学意义(P<0.05)。观察组住院时间与住院费用低于对照组,差异有统计学意义(P<0.05)。观察组不良反应总发生率低于对照组,差异有统计学意义(P<0.05)。治疗前,两组CD4^(+)、CD8^(+)表达水平比较,差异无统计学意义(P>0.05),治疗后,观察组CD4^(+)、CD8^(+)表达水平高于对照组,差异有统计学意义(P<0.05)。结论针对多发性硬化患者,临床进行甲泼尼龙鞘内注射治疗效果较好,可推广应用。Objective To investigate the impact of intrathecal methylprednisolone injection on neurological function and immune function on patients with acute multiple sclerosis.Methods Patients with acute multiple sclerosis were treated in Jilin Neuropsychiatric Hospital from January 2019 to January 2022 were selected and divided into two groups,the control group(n=30)and the observation group(n=30).The control group was treated with intravenous infusion of methylprednisolone,while the observation group was treated with intrathecal injection of methylprednisolone.And the efficacies of the two groups were observed and compared.Results Compared with the control group,the overall response rate of the observation group was higher,the difference was statistically significant(P<0.05).There was no statistically significant difference in the expanded disability status scale(EDSS)scores between the two groups before treatment(P>0.05).After treatment,the EDSS score of the observation group was lower than that of the control group,the difference was statistically significant(P<0.05).And the quality of life in the observation group was higher than that in the control group,the difference was statistically significant(P<0.05).The hospitalization time and expenses in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05),and the adverse reactions in the observation group were lower than those in the control group,the differences were statistically significant(P<0.05).Before treatment,there was no statistically significant difference in the expression levels of CD4^(+) index and CD8^(+) index between the two groups(P>0.05).After treatment,the expression levels of CD4^(+) index and CD8^(+) index of the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).Conclusion For patients with multiple sclerosis,clinical intrathecal injection of methylprednisolone can be promoted.

关 键 词：甲泼尼龙鞘内注射治疗 多发性硬化 神经功能 免疫功能 

分 类 号：R452[医药卫生—治疗学]