芪藤通痹散熏洗及α-硫辛酸联合甲钴胺对糖尿病周围神经病变患者氧化应激指标及炎性因子的影响  

The effects of Qiteng Tongbi powder fumigation washing and α-Lipoic acid combined with mecobalamin on oxidative stress indexes and inflammatory factors in patients with diabetes peripheral neuropathy

作　　者：朱贺 ZHU He(Department of endocrinology,Shenyang Jishuitan Hospital,Shenyang 110000,China)

机构地区：[1]沈阳积水潭医院内分泌科,沈阳市110000

出　　处：《临床合理用药杂志》2023年第14期47-49,53,共4页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的 观察芪藤通痹散熏洗及α-硫辛酸联合甲钴胺对糖尿病周围神经病变(DPN)患者氧化应激指标及炎性因子的影响。方法 选取2018年1月—2020年1月沈阳积水潭医院收治的DPN患者86例,根据随机数字表法分为观察组和对照组,各43例。对照组给予α-硫辛酸联合甲钴胺治疗,观察组在对照组基础上加用芪藤通痹散熏洗治疗。比较2组临床疗效,治疗前后氧化应激[超氧化物歧化酶(SOD)、丙二醛(MDA)]水平及血糖(FBG)、炎性因子[超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)]水平。结果 观察组治疗总有效率为81.40%,高于对照组的48.84%(χ^(2)=10.033,P=0.002);治疗后,2组SOD水平较治疗前升高,MDA水平较治疗前降低,且观察组升高或降低的幅度大于对照组(P均<0.01);2组FBG、hs-CRP、TNF-α水平均较治疗前下降,且观察组低于对照组(P均<0.01)。结论 对DPN患者联合应用芪藤通痹散熏洗和α-硫辛酸、甲钴胺进行治疗,可有效提高治疗效果,改善氧化应激水平,降低FBG及炎性因子水平,值得临床推广与应用。Objective To observe the effects of Qiteng Tongbi powder fumigation washing andα-lipoic acid combined with mecobalamin on oxidative stress indexes and inflammatory factors in patients with diabetes peripheral neuropathy(DPN).Methods 86 patients with DPN admitted to Shenyang Jishuitan Hospital from January 2018 to January 2020 were selected,and divided them into observation group and control group according to random number table method,with 43 patients in each group.The control group was treated withα-lipoic acid combined with mecobalamin,the observation group was treated with Qiteng Tongbi powder fumigation and washing on the basis of the control group.The clinical efficacy,levels of oxidative stress[superoxide dismutase(SOD),malondialdehyde(MDA)],fasting blood glucose(FBG),inflammatory factors[hypersensitive C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α)]before and after treatment were compared between the two groups.Results The total effective rate of treatment in the observation group was 81.40%,higher than 48.84%in the control group(χ^(2)=10.033,P=0.002);After treatment,the level of SOD in both groups increased compared to before treatment,the level of MDA in both groups decreased compared to before treatment,and the increase or decrease in the observation group was greater than that in the control group(all P<0.01).The levels of FBG,hs-CRP,TNF-αin both groups were all lower than before treatment,and the observation group was lower than the control group(all P<0.01).Conclusion Combined application of Qiteng Tongbi powder fumigation and washing,α-lipoic acid and mecobalamin to DPN patients,can effectively improve the treatment effect,improving the level of oxidative stress and reducing the level of FBG and inflammatory factors is worthy of clinical promotion and application.

关 键 词：糖尿病周围神经病变 芪藤通痹散熏洗 Α-硫辛酸 甲钴胺 氧化应激指标 血糖 炎性因子 

分 类 号：R587.2[医药卫生—内分泌]