参麦注射液联合拉贝洛尔治疗妊娠期高血压的疗效及对患者PECAM-1、sVEGFR-1和VEGF水平的影响  

Efficacy of Shenmai injection combined with labetalol in the treatment of gestational hypertension and its effect on serum PECAM-1,sVEGFR-1 and VEGF levels

作　　者：张霞 ZHANG Xia(Department of Obstetrics and Gynecology,Macheng Hospital of Traditional Chinese Medicine,Hubei Province,Macheng 438300,China)

机构地区：[1]湖北省麻城市中医医院妇产科,438300

出　　处：《临床合理用药杂志》2023年第19期13-16,20,共5页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察参麦注射液联合拉贝洛尔治疗妊娠期高血压的疗效及对患者血清血小板内皮细胞黏附分子-1(PECAM-1)、人可溶性血管内皮生长因子受体-1(sVEGFR-1)和血管内皮生长因子(VEGF)水平的影响。方法选取2018年6月—2019年12月麻城市中医医院收治的妊娠期高血压患者99例,应用随机数字表法分为观察组49例和对照组50例。对照组患者予以拉贝洛尔治疗,观察组患者在对照组基础上联合参麦注射液治疗,2组患者均持续治疗7 d。比较2组患者临床疗效,治疗前后血压、脐动脉血流动力学参数[阻力指数(RI)、搏动指数(PI)、收缩末期血流速度最大值(SV)/舒张末期血流速度最大值(DV)(S/D)]及血清PECAM-1、sVEGFR-1、VEGF水平,并统计2组妊娠结局及不良反应。结果观察组患者治疗总有效率为93.88%,高于对照组的78.00%(χ^(2)=5.138,P=0.023)。治疗7 d后,2组患者收缩压、舒张压均显著低于治疗前;2组患者RI、PI、S/D均明显低于治疗前,且观察组低于对照组(P均<0.01);2组患者PECAM-1水平较治疗前升高,sVEGFR-1、VEGF水平较治疗前降低,且观察组上述指标变化较对照组更显著(P<0.05或P<0.01)。观察组早产率、剖宫率均低于对照组(P<0.05);2组新生儿窒息、新生儿死亡发生率比较差异无统计学意义(P>0.05)。结论参麦注射液联合拉贝洛尔治疗妊娠期高血压能更好地控制血压,调节胎盘血流,调节PECAM-1、sVEGFR-1与VEGF水平,改善妊娠结局,且安全性好。Objective To observe the curative effect of Shenmai injection combined with labetalol in the treatment of patients with gestational hypertension and its effect on serum platelet endothelial cell adhesion molecule-1(PECAM-1),human soluble vascular endothelial growth factor receptor-1(sVEGFR-1)and vascular endothelial growth factor(VEGF)levels.Methods 99 patients with hypertensive disorder complicating pregnancy admitted to Macheng Hospital of Traditional Chinese Medicine from June 2018 to December 2019 were selected and divided into observation group(49 cases)and control group(50 cases)by random number table method.The patients in the control group were treated with rabolol,and the patients in the observation group were treated with Shenmai injection on the basis of the control group.The patients in both groups continued to be treated for 7 days.The clinical efficacy,blood pressure,umbilical artery hemodynamic parameters[resistance index(RI),pulsation index(PI),ratio of maximum systolic velocity(SV)to maximum diastolic velocity(DV)(S/D)],and serum PECAM-1,sVEGFR-1,VEGF of two groups levels were compared between the two groups before and after treatment,and the pregnancy outcome and adverse reactions were statistically analyzed.Results The total effective rate of treatment in the observation group was 93.88%,higher than 78.00%in the control group(χ^(2)=5.138,P=0.023).After 7 days of treatment,the systolic and diastolic blood pressure of patients in both groups were significantly lower than those before treatment;The RI,PI and S/D of patients in the two groups were significantly lower than those before treatment,and those in the observation group were lower than those in the control group(P<0.01);The level of PECAM-1 in the two groups was higher than that before treatment,and the levels of sVEGFR-1 and VEGF were lower than those before treatment,and the changes of the above indexes in the observation group were more significant than those in the control group(P<0.05 or P<0.01).The rate of premature delivery and ces

关 键 词：妊娠期高血压 参麦注射液 拉贝洛尔 血小板内皮细胞黏附分子-1 人可溶性血管内皮生长因子受体-1 血管内皮生长因子 

分 类 号：R714.246[医药卫生—妇产科学]