基于网络药理学探究傅氏加味补中益气汤治疗肥胖不孕的分子机制  

Network pharmacology-based analysis of the molecular mechanism ofFu's Modified Buzhong Yiqi Decoction for the treatment of obesity-related infertility

作　　者：刘葭[1] 肖雪[1] 江雯 LIU Jia;XIAO Xue;JIANG Wen(West China Second Hospital of Sichuan University,Chengdu Sichuan610044,China)

机构地区：[1]四川大学华西第二医院,四川成都610044

出　　处：《四川中医》2023年第3期44-48,共5页Journal of Sichuan of Traditional Chinese Medicine

摘　　要：目的:探究傅氏加味补中益气汤治疗肥胖不孕的分子机制。方法:通过TCMSP数据库及UniProt数据库获取加味补中益气汤药物活性成分及作用靶点,结合GeneCard数据库获取肥胖不孕的靶点,采用Cytoscape 3.8.0构建疾病-靶点-药物网络,药物-成分靶点网络。结果:从分子的角度,确定了130个潜在的治疗靶点。根据网络节点参数,共鉴定出5个HUB靶点(MAPK1,MAPK3,AKT1,EGFR和TP53)。从通路水平上,共发现188条有意义的信号通路,包括PI3K-Akt信号通路和MAPK信号通路。结论:加味补中益气汤可能通过干预一系列靶点发挥细胞增殖、抗凋亡和抗炎调节作用,从而改善肥胖不孕。Objective:the mechanism of Fu's Modified Buzhong Yiqi Decoction in obesity-related infertility.Method:active ingredients and action targets of Modified Buzhong Yiqi Decoction were obtained through the TCMSP database and UniProt database.Combined with the GeneCard database to obtain the targets of obesity-related infertility.The disease-target-drug network was constructed by Cytoscape 3.8.0.Results:From a molecular perspective,130potential therapeutic targets were found.Based on the parameter of network nodes,5HUB targets(MAPK1,MAPK3,AKT1,EGFR and TP53)were identified.At the pathway level,a total of 188meaningful signaling pathways were identified,including PI3K-Akt signaling pathways and MAPK signaling pathways.Conclusion:Modified Buzhong Yiqi Decoction improves obesity-related infertility via cell proliferation,anti-apoptosis and anti-inflammatory regulatory effects for treating obesity-related infertility.

关 键 词：肥胖不孕 加味补中益气汤 网络药理学 

分 类 号：R711.6[医药卫生—妇产科学]