复方芪术汤联合HAART治疗艾滋病患者的临床疗效及对免疫功能的影响  

The clinical effect of compound Qishu decoction combined with HAART in the treatment of AIDS patients and its influence on immune function

作　　者：阮克琛[1] 黄子冬[2] RUAN Kechen;HUANG Zidong(Department of infection,Baise people's Hospital,Baise Guangxi533000,China;Department of Traditional Chinese Medicine,Baise people's Hospital,Baise Guangxi533000,China)

机构地区：[1]百色市人民医院感染科,广西百色530000 [2]百色市人民医院中医科,广西百色533000

出　　处：《四川中医》2023年第3期55-58,共4页Journal of Sichuan of Traditional Chinese Medicine

基　　金：百色市科学研究与技术开发计划(项目编号:百科20184204)。

摘　　要：目的:观察复方芪术汤联合高效抗逆转录病毒治疗(HAART)艾滋病(AIDS)患者的临床疗效及对免疫功能的影响。方法:52例AIDS患者选取自我院于2018年5月~2020年5月期间收治的患者。根据双色球法将患者分为对照组和观察组,各26例。对照组给予HARRT治疗,观察组给予复方芪术汤联合HAART治疗,均治疗6个月。对比两组治疗6个月后的临床疗效,对比两组治疗前、治疗6个月后的中医证候积分,对比两组治疗前、治疗3个月后、治疗6个月后的免疫功能变化情况,观察两组治疗期间不良反应发生情况。结果:治疗6个月后,观察组的临床总有效率高于对照组(P<0.05);治疗6个月后,两组便溏、腹胀、乏力、纳差、面色不华、口干舌燥等症状评分均下降,且观察组的下降程度大于对照组(P<0.05);治疗3个月、6个月后,两组CD4^(+)T淋巴细胞水平依次升高,且观察组的升高程度大于对照组(P<0.05)。两组不良反应发生率组间对比无统计学差异(P>0.05)。结论:复方芪术汤联合HAART治疗AIDS患者,可促进临床症状改善,更好的调节机体免疫功能,疗效显著。Objective:To observe the clinical effect of the compound Qishu decoction combined with highly effective antiretroviral(HAART)in the treatment of AIDS patients and the influence on immune function.Methods:52AIDS patients were selected from the patients who were admitted to our hospital from May 2018to May 2020.According to the method of the dichromatic ball,all patients were divided into the control group and the observation group,with 26cases in each group.The control group was treated with HAART for 6months,and the observation group was treated with compound Qishu Decoction and HAART for 6months.We compared the clinical efficacy of the two groups after 6months of treatment,compared the TCM syndrome score of the two groups before and after 6months of treatment,compared the changes in the immune function of the two groups before,after 3months of treatment and after 6months of treatment,and observed the occurrence of adverse reactions during the treatment period of the two groups.Results:After 6months of treatment,the total effective rate of the observation group was higher than the control group(P<0.05).After 6months of treatment,the symptom scores of loose stool,abdominal distension,fatigue,poor appetite,unsmooth face,dry mouth and tongue dryness of the two groups decreased,and the decreased degree of observation group was higher than the control group(P<0.05).After 3months and 6months,the level of CD4^(+)T lymphocytes in the two groups increased in turn,and the level of the observation group was higher than the control group(P<0.05).There was no statistical difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Compound Qishu decoction combined with HAART can improve clinical symptoms and regulate the immune function of the body.

关 键 词：复方芪术汤 高效抗逆转录病毒治疗 艾滋病 临床疗效 免疫功能 

分 类 号：R512.91[医药卫生—内科学]