ABCA1在动脉粥样硬化细胞死亡调控中的作用及研究进展  

Research progress on role of ABCA1 in regulation of cell death in atherosclerosis

作　　者：唐红悦 邢晨皓(综述) 张明明(审校)[2] TANG Hongyue;XING Chenhao;ZHANG Minmin(Graduate School,Hebei North University,Zhangjiakou,Hebei 075000,China;Clinical Medicine Research Center,Hebei General Hospital,Shijiazhuang,Hebei 050051,China)

机构地区：[1]河北北方学院研究生学院,河北张家口075000 [2]河北省人民医院临床医学研究中心,河北石家庄050051

出　　处：《检验医学与临床》2023年第13期1945-1949,共5页Laboratory Medicine and Clinic

基　　金：河北省财政厅政府资助临床医学人才培养项目(2020009)。

摘　　要：动脉粥样硬化(AS)是一种以脂质积聚和炎症为特征的疾病,是冠心病和心肌梗死的病理基础。在AS发展过程中会出现多种形式的细胞死亡,包括胞葬、细胞焦亡与自噬,调控细胞死亡进程可能延缓AS过程。三磷酸腺苷结合盒转运体(ABC)A1是细胞内胆固醇外流的关键介质,在胆固醇逆向转运中生成高密度脂蛋白。目前,越来越多研究发现,细胞死亡与AS密切相关,但具体机制尚未阐明。该文综述了ABCA1调控细胞死亡,如胞葬、细胞焦亡和自噬对AS的影响。Atherosclerosis(AS)is a disease characterized by lipid accumulation and inflammation,which is the pathological basis of coronary heart disease and myocardial infarction.Various forms of cell death may occur during the development of AS,including efferocytosis,pyroptosis and autophagy.The regulation of cell death process may delay the process of AS.ATP-binding cassette transporter A1(ABCA1)is a key mediator in the efflux of intracellular cholesterol,and high density lipoprotein is generated in the reverse transport of cholesterol.At present,more and more studies have found that cell death is closely related to the AS,but the specific mechanism has not been clarified.This article reviews the effects of ABCA1 on AS by regulating cell death,such as efferocytosis,pyroptosis and autophagy.

关 键 词：动脉粥样硬化 三磷酸腺苷结合盒转运体A1 胞葬 细胞焦亡 自噬 

分 类 号：R543.5[医药卫生—心血管疾病]