中药穴位贴敷联合益气健脾汤对慢性心力衰竭康复及远期生活质量的影响研究  

Effect of traditional Chinese medicine acupoint application combined with YiqiJianpiDecoctionon the rehabilitation and long-term quality of life of chronic heart failure

作　　者：田琼[1] 万丛亚 TIAN Qiong;WAN Cong-ya

机构地区：[1]南阳市第一人民医院静脉药物调配中心,河南南阳473000

出　　处：《中国疗养医学》2023年第8期858-861,共4页Chinese Journal of Convalescent Medicine

基　　金：河南省医学科技攻关项目(LHGJ202101173)。

摘　　要：目的观察中药穴位贴敷联合益气健脾汤对慢性心力衰竭患者心功能康复效果及远期生活质量的影响。方法本次研究以2021年1月至2022年2月南阳市第一人民医院收治的123例慢性心力衰竭患者为研究对象,采用电脑随机分组法将其分为中药组(63例)和西药组(60例),西药组采用常规西药治疗,中药组采用中药穴位贴敷联合益气健脾汤治疗,比较两组患者治疗前后的心血管血清因子、心脏超声检查结果,对入组患者开展为期1年随访,统计并对比两组患者的用药副反应发生情况及远期生活质量。结果治疗前,两组患者的心血管血清因子及心功能指标差异无统计学意义(P>0.05);治疗后,中药组的可溶性生长刺激表达基因2蛋白(sST2)为(85.77±10.26)ng/mL,生长分化因子15(GDF-15)为(825.33±100.61)ng/L,均低于西药组(92.44±15.25)ng/mL、(1024.77±150.33)ng/L,差异具有统计学意义(P<0.05)。治疗后,中药组的左室射血分数(LVEF)为(55.26±10.41)%,每分钟搏出量(SV)为(58.42±10.36)mL,心排血量(CO)为(4.45±1.27)L/min,均高于西药组(48.33±10.28)%、(51.25±10.62)mL、(3.87±0.46)L/min,差异具有统计学意义(P<0.05)。随访期间,中药组的药物副反应发生率7.94%(5/63)低于西药组23.33%(14/60),差异具有统计学意义(P<0.05)。观察组随访第1个月时的明尼苏达生活质量问卷(MLHFQ)评分为(40.24±8.26)分,第6个月时的MLHFQ评分为(33.41±5.57)分,第12个月时的MLHFQ评分为(26.77±5.18)分,均低于西药组(45.62±10.33)分、(38.25±8.19)分、(30.44±5.71)分,差异具有统计学意义(P<0.05)。结论穴位贴敷和益气健脾汤中药治疗能改善慢性心力衰竭患者心功能康复效果,对降低药物副反应风险并提升远期生活质量均有积极意义。Objective To explore the effect of traditional Chinese medicine(TCM)acupoint application combined with YiqiJianpi Decoctionon the rehabilitation and long-term quality of life in patients with chronic heart failure(CHF).Methods A total of 123 patients with CHF admitted in the Nanyang First People's Hospital between January 2021 and February 2022 were recruited.They were divided into TCM group(n=63)and Western medicine group(n=60)using computer randomization.Conventional Western medicine,and the TCM acupoint application combined with YiqiJianpi Decoction were applied to patients of Western medicine group and TCM group,respectively.Cardiovascular serum factors and cardiac ultrasound results of patients in both groups before and after treatment were compared.They were followed up for 1 year,and the incidence of drug side effects and long-term quality of life were compared between the two groups.Results Before treatment,there were no significant differences in cardiovascular serum factors and cardiac function indicators between the two groups(P>0.05).After treatment,serum levels of somatostatin receptor 2(sST2[85.77±10.26]ng/mL VS[92.44±15.25]ng/mL)and growth/differentiation factor-1(GDF-15[825.33±100.61]ng/L VS[1024.77±150.33]ng/L)in the TCM group were significantly lower than those in the Western medicine group(P<0.05).After treatment,the left ventricular ejection fraction(LVEF[55.26±10.41]%VS[48.33±10.28]%),stroke volume(SV[58.42±10.36]mL VS[51.25±10.62]mL)and cardiac output(CO[4.45±1.27]L/min VS[3.87±0.46]L/min)in the TCM group were significantly higher than those in the Western medicine group(P<0.05).During the follow-up period,the incidence of drug side effects in the TCM group was significantly lower than that in the Western medicine group(7.94%[5/63]VS 23.33%[14/60],P<0.05).The Minnesota Living with Heart Failure Questionnaire(mLHFQ)scores at 1 month(40.24±8.26)points VS(45.62±10.33)points,6 months(33.41±5.57)points VS(38.25±8.19)points and 12 months(26.77±5.18)points VS(30.44±5.71)pointswere s

关 键 词：慢性心力衰竭 穴位贴敷 益气健脾汤 心功能 用药安全性 生活质量 

分 类 号：R259[医药卫生—中西医结合]