基因多态性在预测IVIG无应答型川崎病中的研究进展  

Research progress of gene polymorphism in predicting IVIG non-response Kawasaki disease

作　　者：高源 隋铭泽 梁妍琰 朱华 Gao Yuan;Sui Mingze;Liang Yanyan;Zhu Hua(Inner Mongolia Clinical College Autonomous,Inner Mongolia Medical University,Hohhot 010020,China;Department of Pediatrics,Inner Mongolia Region People′s Hospital,Hohhot 010017,China;Department of Pediatrics,Hainan General Hospital,Haikou 570311,China)

机构地区：[1]内蒙古医科大学内蒙古临床医学院,呼和浩特010020 [2]内蒙古自治区人民医院儿科,呼和浩特010017 [3]海南省人民医院儿科,海口570311

出　　处：《国际遗传学杂志》2023年第2期131-138,共8页International Journal of Genetics

摘　　要：川崎病(Kawasaki disease,KD)是一种非特异性全身中小血管炎,规范静脉注射丙种球蛋白(intravenous immunoglobulin,IVIG)联合阿司匹林口服可降低冠状动脉损害(coronary artery lesion,CAL)的发生率。由于部分患儿存在IVIG无应答致使CAL的发生率明显升高,因此预测IVIG无应答为目前的研究重点。本文就基因多态性与IVIG无应答型KD的相关性进行综述。Kawasaki disease(KD)is a nonspecific systemic small and medium-sized vasculitis,coronary artery damage(CAL)is the most serious complication,and standardized intravenous immunoglobulin(IVIG)therapy reduces the incidence of complications.The incidence of CAL was significantly higher in some children,and predicting IVIG non-response and giving reinforcement measures helped improve prognosis.The role of gene polymorphisms in susceptibility to KD has been demonstrated,and the correlation between gene polymorphisms and IVIG-unresponsive KD has attracted attention from scholars in recent years.Exploring genes associated with IVIG non-response is beneficial for early prediction of IVIG non-response.

关 键 词：川崎病 静脉滴注丙种球蛋白无应答 基因多态性 单核苷酸多态性 

分 类 号：R725.4[医药卫生—儿科]