Ethnopharmacological,phytochemical and clinical studies on Fenugreek(Trigonella foenum-graecum L.)  

作　　者：Neetu Singh Surender Singh Yadav Sanjiv Kumar Balasubramaniam Narashiman 

机构地区：[1]Department of Botany,Maharshi Dayanand University,Rohtak,Haryana,124001,India [2]Department of Pharmaceutical Sciences,Ch.Bansi Lal University,Bhiwani,Haryana,India [3]Department of Pharmaceutical Sciences,M.D.University,Rohtak,Haryana,124001,India

出　　处：《Food Bioscience》2022年第2期24-54,共31页食品生物科学（英文）

基　　金：The financial assistance from Haryana State Council for Science and Technology(HSCST)and Council for Scientific and Industrial Research(CSIR),New Delhi and DST-FIST,New Delhi is thankfully acknowledged.

摘　　要：Trigonella foenum-graecum(fenugreek)belonging to the family Fabaceae,is widely used for both culinary as well as clinical purposes since antiquity.Folkloric medicines across globe particularly use this plant for boosting immunity and combating digestive and reproductive impairments.The plant is rich reservoir of different phytoconstituents attributed to their diverse pharmacological effects.Therefore,the present article is planned on its ethnomedicinal uses,botanical description,phytochemistry,pharmacology,toxicology,clinical efficacy,mechanism of action and nanoparticle synthesis.In all pharmacological studies,the dose,major bioactive,type of extract and possible outcomes is also discussed,to establish its specific role against a particular ailment.It was hypothesized that the nanoparticle synthesis will lead to the enhanced pharmacology.Results showed that ethnomedicinal data well supports the different pharmacological aspects of Trigonella formulations in different countries.Trigonelline(phytoestrogen)renders most of therapeutic potential of Trigonella.The reported therapeutics can also be accounted as the synergistic pharmacology of different bioactives.Nanoparticle synthesis significantly improves its pharmacological efficacy.Clinical studies well validated its antidiabetic and reproductive health improving efficacies.Though no serious toxic effects were observed with the use of this plant but further well-designed placebo trials are still needed to demonstrate its full therapeutic potential.

关 键 词：TRIGONELLA FENUGREEK Traditional uses Pharmacology Clinical study Toxicology 

分 类 号：O62[理学—有机化学]